大鼠纹状体异质性的进一步证实：甲基苯丙胺或利血平给药后多巴胺纤维的不同镶嵌模式。

Further confirmation of heterogeneity of the rat striatum: different mosaic patterns of dopamine fibers after administration of methamphetamine or reserpine.

作者信息

Fukui K, Kariyama H, Kashiba A, Kato N, Kimura H

出版信息

Brain Res. 1986 Sep 10;382(1):81-6. doi: 10.1016/0006-8993(86)90113-7.

Abstract

Heterogeneity of adult rat neostriatum has been studied by fluorescence histochemistry. The distribution of dopamine nerve fibers and terminals, known normally to be homogeneous, tended to become heterogeneous after administration of methamphetamine or reserpine. Both drugs caused mosaic formations of fluorescent dopamine axons and terminals, though a minor difference was present in the pattern of distribution. The results indicate that the striatum possesses at least two types of dopamine nerve terminals, sensitive and relatively insensitive for the two catecholamine depletors.

摘要

通过荧光组织化学研究了成年大鼠新纹状体的异质性。多巴胺神经纤维和终末的分布通常是均匀的，但在给予甲基苯丙胺或利血平后倾向于变得不均匀。两种药物都导致了荧光多巴胺轴突和终末的镶嵌形成，尽管在分布模式上存在细微差异。结果表明，纹状体至少拥有两种类型的多巴胺神经终末，对这两种儿茶酚胺耗竭剂分别敏感和相对不敏感。