Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USA.
Ferkauf Graduate School of Psychology, Yeshiva University, 500 West 185th Street, New York, NY 10033, USA.
Nutrients. 2023 Aug 31;15(17):3808. doi: 10.3390/nu15173808.
Brain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy density food (HEF and LEF, respectively) and non-food (NF) visual cues. A region of interest (ROI) analysis compared BE participants to NB participants in those undergoing RYGB surgery pre-surgery and 4 months post. Results were corrected for multiple comparisons using liberal ( < 0.006 uncorrected) and stringent ( < 0.05 FDR corrected) thresholds. Four months following RYGB (vs. no treatment (NT) control), both BE and NB participants showed greater reductions in blood oxygen level-dependent (BOLD) signals (a proxy of local brain activity) in the dorsomedial prefrontal cortex in response to HEF (vs. LEF) cues ( < 0.006). BE (vs. NB) participants showed greater increases in the precuneus ( < 0.006) and thalamic regions ( < 0.05 corrected) to food (vs. NF). For RYGB (vs. NT) participants, BE participants, but not NB participants, showed lower BOLD signal in the middle occipital gyrus ( < 0.006), whilst NB participants, but not BE participants, showed lower signal in inferior frontal gyrus ( < 0.006) in response to HEF (vs. LEF). Results suggest distinct neural mechanisms of RGYB in BE and may help lead to improved clinical treatments.
脑对食物线索的反应活动在接受 Roux-en-Y 胃旁路术（RYGB）的暴食（BE）或非暴食（NB）个体中研究较少。在这里，15 名 RYGB（8 名 BE；7 名 NB）和 13 名无治疗（NT）（7 名 BE；6 名 NB）肥胖女性在观看高和低能量密度食物（HEF 和 LEF，分别）和非食物（NF）视觉线索时进行 fMRI 成像。在接受 RYGB 手术的患者中，对感兴趣区域（ROI）的分析将 BE 参与者与 NB 参与者进行了比较，比较了手术前和手术后 4 个月的情况。结果使用宽松（<0.006 未校正）和严格（<0.05 FDR 校正）阈值进行了多次比较校正。RYGB 手术后 4 个月（与无治疗（NT）对照相比），BE 和 NB 参与者在背内侧前额叶皮层对 HEF（与 LEF 相比）线索的反应中，血液氧水平依赖性（BOLD）信号（局部脑活动的代表）均显示出更大的降低（<0.006）。与 NF 相比，BE（与 NB 相比）参与者的楔前叶（<0.006）和丘脑区域（<0.05 校正）对食物的反应更大。对于 RYGB（与 NT 相比）参与者，BE 参与者，而不是 NB 参与者，在中脑回（<0.006）的 BOLD 信号降低，而 NB 参与者，而不是 BE 参与者，在额下回（<0.006）的信号降低对 HEF（与 LEF）的反应。结果表明 RYGB 在 BE 中的神经机制不同，这可能有助于改善临床治疗。
