Lai Chun-Feng, Shiau Fu-Jia
Department of Photonics, Feng Chia University, Taichung 407, Taiwan.
Nanomaterials (Basel). 2023 Aug 28;13(17):2441. doi: 10.3390/nano13172441.
Contact lenses (CLs) have emerged as an effective method for delivering ophthalmic drugs. In this research, we designed hydrogel CLs capable of extended release, utilizing large-pore mesoporous silica nanoparticles (LPMSNs) to deliver hyaluronic acid (HA) for treating dry eye syndrome. LPMSNs were functionalized with amine groups (LPMSN-amine) to enhance HA loading and release capacity. In vitro release studies demonstrated that LPMSN-amine CLs exhibited superior slower HA release than LPMSN-siloxane and standard CLs. Within 120 h, the cumulative amount of HA released from LPMSN-amine CLs reached approximately 275.58 µg, marking a 12.6-fold improvement compared to standard CLs, when loaded from 0.1 wt% HA solutions. Furthermore, LPMSN-amine CLs effectively maintained moisture, mitigating ocular surface dehydration, making them a promising solution for dry eye management. This study successfully developed LPMSN-amine CLs for extended HA release, identifying the optimal functional groups and loading conditions to achieve sustained release.
隐形眼镜（CLs）已成为一种有效的眼科药物递送方法。在本研究中，我们设计了能够实现缓释的水凝胶隐形眼镜，利用大孔介孔二氧化硅纳米颗粒（LPMSNs）递送透明质酸（HA）来治疗干眼症。LPMSNs用胺基进行功能化（LPMSN-胺）以提高HA的负载和释放能力。体外释放研究表明，LPMSN-胺隐形眼镜比LPMSN-硅氧烷隐形眼镜和标准隐形眼镜表现出更优异的较慢HA释放。在120小时内，当从0.1 wt% HA溶液加载时，LPMSN-胺隐形眼镜释放的HA累积量达到约275.58μg，与标准隐形眼镜相比提高了12.6倍。此外，LPMSN-胺隐形眼镜有效地保持了水分，减轻了眼表脱水，使其成为干眼症治疗的一种有前景的解决方案。本研究成功开发了用于HA缓释的LPMSN-胺隐形眼镜，确定了实现持续释放的最佳官能团和负载条件。
