Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 1591634311, Iran.
Department of Biomaterials, Faculty of Science, Iran Polymer and Petrochemical Institute, Tehran, 1311514977, Iran.
Macromol Biosci. 2021 Jul;21(7):e2100043. doi: 10.1002/mabi.202100043. Epub 2021 May 20.
Here, a novel ring-implanted poly vinyl alcohol (PVA) contact lens (CL) is fabricated and evaluated as a therapeutic CL with potential of sustained release of hyaluronic acid (HA). HA is loaded on chitosan (CS) nanoparticles (NPs) and then the HA-loaded NPs are dispersed in a ring shape PVA hydrogel which is implanted in the final PVA CL. Results show that HA is successfully loaded on NPs (520 ± 18 nm) with loading efficacy of 87% and loading capacity of 50%. The CL hydrogel has a 275% swelling ratio, no degradation during 14 days, 97% light transmittance, and desirable rheological stability under physiological shear force. The release data show a sustained release for HA from the ring implanted CL up to 14 days. The cellular study reveals no corneal epithelial cell cytotoxicity and cell attachment on the CL. The study demonstrates the successful application of the ring-implanted CL to sustain the delivery of HA for treating the dry eye syndrome.
在这里，我们制备了一种新型的环植入聚（乙烯醇）（PVA）隐形眼镜（CL），并将其评估为具有潜在的透明质酸（HA）持续释放功能的治疗性 CL。HA 被负载在壳聚糖（CS）纳米颗粒（NPs）上，然后将负载 HA 的 NPs 分散在环形 PVA 水凝胶中，最终植入 PVA CL。结果表明，HA 成功地负载在 NPs 上（520±18nm），载药率为 87%，载药量为 50%。CL 水凝胶的溶胀比为 275%，在 14 天内无降解，光透过率为 97%，在生理剪切力下具有良好的流变稳定性。释放数据表明，HA 可以从环植入的 CL 中持续释放长达 14 天。细胞研究表明，CL 对角膜上皮细胞没有细胞毒性，细胞可以附着在 CL 上。该研究证明了环植入 CL 在持续输送 HA 治疗干眼症方面的成功应用。
