Nanas J N, Anastasiou-Nana M I, Sutton R B, Menlove R L, Tsagaris T J
Can J Cardiol. 1986 Jul-Aug;2(4):195-9.
The Fick and indicator-dilution techniques for measurement of cardiac output (CO) were compared at rest in 1,022 patients and in 786 during exercise. Duplicate measurements of dye CO at rest revealed that 92.7% fell within 10% of the line of identity and 99% within 20%. For the resting Fick and dye comparisons, 44.6% were within 10% of the identity line and 74.7% within 20%. When mean CO was less than 4.4 L/min, dye CO was higher than Fick. This relationship persisted for CO between 4.4 and 7.4 whereas for above 7.4 L/min, Fick was higher than dye. During exercise, 50.2% of the Fick and dye comparisons fell within 10% and 77.1% within 20% of the line of identity. There was a systematic difference between the two methods during exercise with dye CO higher than Fick CO. This study agrees with Fick and dye comparison studies with 74.7% and 77.1% of values within 20% of the identity line during rest and exercise, respectively. However, these results differ from others in that dye CO was higher than Fick CO for low and normal values whereas Fick was greater for the higher CO values. The overall agreement between the two methods in a large group of patients with diverse cardiac diseases over a broad spectrum of CO values supports use of either method for clinical studies.
在1022例患者静息状态下以及786例患者运动状态下，对用于测量心输出量（CO）的菲克法和指示剂稀释技术进行了比较。静息状态下重复测量染料心输出量结果显示，92.7%的数据落在一致性线的10%范围内，99%的数据落在20%范围内。对于静息状态下菲克法和染料法的比较，44.6%的数据落在一致性线的10%范围内，74.7%的数据落在20%范围内。当心输出量均值小于4.4L/min时，染料心输出量高于菲克法测量值。这种关系在4.4至7.4L/min的心输出量范围内持续存在，而在心输出量高于7.4L/min时，菲克法测量值高于染料法。在运动过程中，菲克法和染料法比较结果中，50.2%的数据落在一致性线的10%范围内，77.1%的数据落在20%范围内。运动过程中两种方法存在系统性差异，染料心输出量高于菲克心输出量。本研究与其他菲克法和染料法比较研究结果相符，静息和运动状态下分别有74.7%和77.1%的数据落在一致性线的20%范围内。然而，这些结果与其他研究不同之处在于，在低心输出量和正常心输出量时染料心输出量高于菲克心输出量，而在心输出量较高时菲克法测量值更大。在一大组患有多种心脏疾病、心输出量范围广泛的患者中，两种方法的总体一致性支持在临床研究中使用任何一种方法。
