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用于生物传感应用的高性能 Cu 基表面等离子体共振传感器的数值研究。

Numerical Investigation on High-Performance Cu-Based Surface Plasmon Resonance Sensor for Biosensing Application.

机构信息

Department of ECE, Vel Tech Rangarajan Dr Sagunthala R & D Institute of Science and Technology, Chennai 600025, Tamil Nadu, India.

Department of Physics, Chikkanna Government Arts College, Tiruppur 641602, Tamil Nadu, India.

出版信息

Sensors (Basel). 2023 Aug 29;23(17):7495. doi: 10.3390/s23177495.

Abstract

This numerical research presents a simple hybrid structure comprised of TiO-Cu-BaTiO for a modified Kretschmann configuration that exhibits high sensitivity and high resolution for biosensing applications through an angular interrogation method. Recently, copper (Cu) emerged as an exceptional choice as a plasmonic metal for developing surface plasmon sensors (SPR) with high resolution as it yields finer, thinner SPR curves than Ag and Au. As copper is prone to oxidation, especially in ambient conditions, the proposed structure involves the utilization of barium titanate (BaTiO) film as a protection layer that not only preserves Cu film from oxidizing but enhances the performance of the sensor to a great extent. Numerical results also show that the utilization of a thin adhesive layer of titanium dioxide (TiO) between the prism base and Cu film not only induces strong interaction between them but also enhances the performance of the sensor. Such a configuration, upon suitable optimization of the thickness of each layer, is found to enhance sensitivity as high as 552°/RIU with a figure of merit (FOM) of 136.97 RIU. This suggested biosensor design with enhanced sensitivity is expected to enable long-term detection with greater accuracy and sensitivity even when using Cu as a plasmonic metal.

摘要

本数值研究提出了一种简单的混合结构,由 TiO-Cu-BaTiO 组成,用于改进的 Kretschmann 配置,通过角度询问方法,该配置表现出高灵敏度和高分辨率,可用于生物传感应用。最近,铜 (Cu) 作为一种等离子体金属脱颖而出,可用于开发具有高分辨率的表面等离子体传感器 (SPR),因为它比 Ag 和 Au 产生更精细、更薄的 SPR 曲线。由于铜容易氧化,尤其是在环境条件下,所提出的结构涉及使用钛酸钡 (BaTiO) 薄膜作为保护层,不仅可以防止 Cu 薄膜氧化,而且可以在很大程度上提高传感器的性能。数值结果还表明,在棱镜基底和 Cu 薄膜之间使用一层薄的二氧化钛 (TiO) 粘合层不仅可以诱导它们之间的强烈相互作用,而且可以增强传感器的性能。这种配置,通过适当优化各层的厚度,被发现可以将灵敏度提高到高达 552°/RIU,品质因数 (FOM) 为 136.97 RIU。这种具有增强灵敏度的建议生物传感器设计有望实现长期检测,具有更高的准确性和灵敏度,即使使用 Cu 作为等离子体金属也是如此。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb81/10490717/a36cc45031f0/sensors-23-07495-g001.jpg

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