Walaszek Z, Hanausek-Walaszek M, Webb T E
Cancer Lett. 1986 Oct;33(1):25-32. doi: 10.1016/0304-3835(86)90098-4.
Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium D-glucarate, an in vivo beta-glucuronidase inhibitor, reduced the steady state level of both beta-glucuronidase and 17-ketosteroid excretion in the highly susceptible A/He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the A/He strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[a]pyrene.
血清β-葡萄糖醛酸酶活性在以下品系小鼠中呈现出定量差异，按活性递增顺序排列如下：C3H、C57BL/6低于BALB/c、DBA/2、ICR低于SENCAR、A/He。已表明小鼠品系中的酶水平与17-酮类固醇的尿排泄相关，而17-酮类固醇的尿排泄又反映了雄激素的内源性水平。膳食钙-D-葡萄糖醛酸酯是一种体内β-葡萄糖醛酸酶抑制剂，它将高度易感的A/He和SENCAR品系中β-葡萄糖醛酸酶和17-酮类固醇排泄的稳态水平降低至已知对化学致癌有抗性的品系的水平。膳食钙葡萄糖醛酸酯显著降低了A/He品系的敏感性，已表明它可抑制苯并[a]芘的DNA结合及肺腺瘤诱导。
