School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin, China; Key Laboratory of Advanced Manufacturing and Intelligent Technology, Ministry of Education, Harbin University of Science and Technology, Harbin, China.
School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin, China; Key Laboratory of Advanced Manufacturing and Intelligent Technology, Ministry of Education, Harbin University of Science and Technology, Harbin, China.
Appl Radiat Isot. 2023 Nov;201:111014. doi: 10.1016/j.apradiso.2023.111014. Epub 2023 Sep 5.
The use of radiotherapy in tumor treatment has become increasingly prominent and has emerged as one of the main tools for treating malignant tumors. Current radiation therapy for glioma employs I seeds for brachytherapy, which cannot be combined with radiotherapy and chemotherapy. To address this limitation, this paper proposes a dual-microcavity capsule structure that integrates radiotherapy and chemotherapy. The Monte Carlo simulation method is used to simulate the structure of the dual-microcavity capsule with a I liquid radioactive source. Based on the simulation results, two kinds of dual-microcavity capsule structures are optimized, and the optimized dual-microcavity capsule structure is obtained. Finally, the dosimetric parameters of the two optimized dual-microcavity capsule structures are analyzed and compared with those of other I seeds. The optimization tests show that the improved dual-capsule dual-microcavity structure is more effective than the single-capsule dual-microcavity structure. At an activity of 5 mCi, the average absorbed dose rate is 71.2 cGy/h in the center of the optimized dual-capsule dual-microcavity structure and 45.8 cGy/h in the center of the optimized single-capsule dual-microcavity structure. Although the radial dose function and anisotropy function exhibite variations from the data of other I seeds, they are generally similar. The absorbed dose rate decreases exponentially with increasing distance from the center of the capsule, which can reduce the damage to the surrounding tissues and organs while increasing the dose. The capsule structure has a better irradiation effect than conventional I seeds and can accomplish long-term, stable, low-dose continuous irradiation to form local high-dose radiation therapy for glioma.
放射治疗在肿瘤治疗中的应用日益突出，已成为治疗恶性肿瘤的主要手段之一。目前用于脑胶质瘤的放射治疗采用 I 种子近距离治疗，但不能与放化疗相结合。针对这一局限性，本文提出了一种集放化疗于一体的双微腔胶囊结构。采用蒙特卡罗模拟方法对具有 I 液放射性核素的双微腔胶囊结构进行模拟。基于模拟结果，对两种双微腔胶囊结构进行了优化，并得到了优化的双微腔胶囊结构。最后，对两种优化后的双微腔胶囊结构的剂量学参数进行了分析，并与其他 I 种子进行了比较。优化测试表明，改进后的双胶囊双微腔结构比单胶囊双微腔结构更有效。在 5 mCi 的活度下，优化后的双胶囊双微腔结构中心处的平均吸收剂量率为 71.2 cGy/h，优化后的单胶囊双微腔结构中心处的平均吸收剂量率为 45.8 cGy/h。虽然径向剂量函数和各向异性函数与其他 I 种子的数据有所不同，但总体上相似。吸收剂量率随距胶囊中心距离的增加呈指数下降，既能减少对周围组织和器官的损伤，又能增加剂量。胶囊结构的照射效果优于传统的 I 种子，可以实现长期、稳定、低剂量的持续照射，形成局部高剂量的脑胶质瘤放射治疗。
