Department of Neurosurgery, Children's Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
The First School of Clinical Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Chemosphere. 2023 Nov;341:140084. doi: 10.1016/j.chemosphere.2023.140084. Epub 2023 Sep 7.
The association between metals and stroke has been reported, but the mediating role of inflammation between metals and stroke remains unclear.
We included 9326 adults from the National Health and Nutrition Examination Survey in this study. Through least absolute selection and shrinkage operator (LASSO) regression, weighted quantile sum (WQS) regression, logistic regression, linear regression, restricted cubic spline analysis, and mediation analysis, we explored the association between metals and stroke, as well as the association between metals and inflammatory indicators, and further evaluated the mediating effect of inflammatory indicators on the association between selected metals and stroke risk.
The results of the present study suggested positive associations between mixed metals, cadmium and uranium and stroke risk. There is a positive correlation and dose‒response relationship between cadmium and C-reactive protein (CRP). Moreover, CRP mediates 10.1% of the association between cadmium and stroke.
At the epidemiological level, CRP mediates the association between cadmium and stroke risk, suggesting that inflammation may be a potential mechanism for metal-induced stroke.
已有研究报道金属与中风之间存在关联，但金属与中风之间的炎症中介作用尚不清楚。
我们纳入了这项研究中的 9326 名成年人，他们来自全国健康和营养调查。通过最小绝对收缩和选择算子（LASSO）回归、加权分位数总和（WQS）回归、逻辑回归、线性回归、限制性立方样条分析和中介分析，我们探讨了金属与中风之间的关联，以及金属与炎症指标之间的关联，并进一步评估了炎症指标对选定金属与中风风险关联的中介作用。
本研究结果表明，混合金属、镉和铀与中风风险呈正相关。镉与 C 反应蛋白（CRP）之间存在正相关和剂量-反应关系。此外，CRP 介导了 10.1%的镉与中风之间的关联。
在流行病学水平上，CRP 介导了镉与中风风险之间的关联，提示炎症可能是金属诱导中风的潜在机制。
