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血液铅含量介导了生物老化与高血压之间的关系：基于 NHANES 数据库。

Blood Lead Mediates the Relationship between Biological Aging and Hypertension: Based on the NHANES Database.

机构信息

Guangxi Crucial Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning 530021, China.

Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Life Science Institute, Guangxi Medical University, Nanning 530021, China.

出版信息

Nutrients. 2024 Jul 5;16(13):2144. doi: 10.3390/nu16132144.

DOI:10.3390/nu16132144
PMID:38999891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11243065/
Abstract

Hypertension remains a major global public health crisis due to various contributing factors, such as age and environmental exposures. This study delves into exploring the intricate association between biological aging, blood lead levels, and hypertension, along with examining the mediating role of blood lead levels in the relationship between biological aging and hypertension. We analyzed data from two cycles of the NHANES, encompassing 4473 individuals aged 18 years and older. Our findings indicate that biological aging potentially escalates the risk of hypertension and the incidences of systolic blood pressure (SBP) and diastolic blood pressure (DBP) abnormalities. Utilizing weighted quantile sum (WQS) and quantile g-computation (QGC) model analyses, we observed that exposure to heavy metal mixtures, particularly lead, may elevate the likelihood of hypertension, SBP, and DBP abnormalities. Further mediation analysis revealed that lead significantly mediated the relationship between biological aging and hypertension and between biological aging and SBP abnormalities, accounting for 64% (95% CI, 49% to 89%) and 64% (95% CI, 44% to 88%) of the effects, respectively. These outcomes emphasize the criticality of implementing environmental health measures.

摘要

由于各种因素的影响，如年龄和环境暴露，高血压仍然是一个主要的全球公共卫生危机。本研究深入探讨了生物老化、血铅水平与高血压之间的复杂关系，并研究了血铅水平在生物老化与高血压之间关系中的中介作用。我们分析了来自 NHANES 两个周期的数据，共纳入了 4473 名 18 岁及以上的个体。我们的研究结果表明，生物老化可能会增加高血压和收缩压（SBP）和舒张压（DBP）异常的风险。利用加权分位数总和（WQS）和分位数计算（QGC）模型分析，我们发现暴露于重金属混合物，特别是铅，可能会增加高血压、SBP 和 DBP 异常的可能性。进一步的中介分析表明，铅显著介导了生物老化与高血压之间以及生物老化与 SBP 异常之间的关系，分别占效应的 64%（95%CI，49%至 89%）和 64%（95%CI，44%至 88%）。这些结果强调了实施环境健康措施的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/b04359a16f9d/nutrients-16-02144-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/e1620f7802b3/nutrients-16-02144-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/1352e31ddef2/nutrients-16-02144-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/4e75076d0aaf/nutrients-16-02144-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/754485a84aab/nutrients-16-02144-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/070186fbff45/nutrients-16-02144-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/b04359a16f9d/nutrients-16-02144-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/e1620f7802b3/nutrients-16-02144-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/1352e31ddef2/nutrients-16-02144-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/4e75076d0aaf/nutrients-16-02144-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/754485a84aab/nutrients-16-02144-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/070186fbff45/nutrients-16-02144-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c30b/11243065/b04359a16f9d/nutrients-16-02144-g006.jpg

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