Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China.
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Sci Bull (Beijing). 2023 Oct 30;68(20):2477-2486. doi: 10.1016/j.scib.2023.08.050. Epub 2023 Aug 30.
The persistence of pathological memory is the basis of several psychiatric disorders. Memory retrieval induces "reconsolidation", a time interval during which the original memory becomes labile and destabilized. Time- and retrieval-dependent processes and memory reconsolidation are critical periods for memory interference. Modulating memory reconsolidation has received considerable research attention as a treatment protocol for several psychiatric conditions such as posttraumatic stress disorder, addiction, anxiety, and trauma-related disorders. This specific time window provides an opportunity for intervention regarding mental diseases. This article reviews the effect of modulating memory reconsolidation using behavioral-, brain stimulation-, and pharmacological-based interventions, which may help bridge the gap between intervention in laboratories and application in clinical practice. The potential advantages, limitations, challenges, and opportunities for memory reconsolidation manipulations were discussed.
病理性记忆的持续是几种精神障碍的基础。记忆提取会诱导“再巩固”，这是一个时间段，在此期间原始记忆变得不稳定。时间依赖和检索依赖的过程以及记忆再巩固是记忆干扰的关键时期。调节记忆再巩固作为创伤后应激障碍、成瘾、焦虑和与创伤相关的障碍等几种精神疾病的治疗方案受到了相当多的研究关注。这个特定的时间窗口为治疗精神疾病提供了一个干预的机会。本文综述了使用行为、脑刺激和药物干预调节记忆再巩固的效果，这可能有助于弥合实验室干预和临床应用之间的差距。讨论了记忆再巩固操作的潜在优势、局限性、挑战和机会。
