从水果中提取的修饰紫铆素衍生物作为抗阿尔茨海默病药物的研究方法。
approach of Modified Embelin derivative from fruits as anti-Alzheimer agent.
作者信息
Rupesh R, Mohankumar R, Sabarathinam Sarvesh
机构信息
Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, India.
Drug Testing Laboratory (DTL), Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, India.
出版信息
Nat Prod Res. 2025 Jan;39(1):208-212. doi: 10.1080/14786419.2023.2255920. Epub 2023 Sep 10.
Embelin is one of the primary compounds present in the fruit. Embelin has a broader pharmacological activity such as Anti-inflammatory, anti-bacterial, antioxidant, and many more. The ultimate aim of the study is to ensure the impact of reduced embelin in the management of Alzheimer's disease. Embelin was isolated and modified by the reduction method, and the Modified Embelin derivative (MED) 3-Undecylcyclohexa-2,5-diene-1,2,4,5-tetraol was analysed through FT-IR, NMR, and Mass Spectroscopic techniques. MED was docked against acetylcholinesterase (AChE) amyloid beta (Aβ) receptors PDB ID: 1EVE & 1B68, respectively. The docking scores remain similar to that of positive standards galantamine and Donepezil.
紫铆因是该果实中存在的主要化合物之一。紫铆因具有更广泛的药理活性，如抗炎、抗菌、抗氧化等等。该研究的最终目的是确定减少紫铆因对阿尔茨海默病治疗的影响。通过还原方法分离并修饰了紫铆因，采用傅里叶变换红外光谱（FT-IR）、核磁共振（NMR）和质谱技术对修饰后的紫铆因衍生物（MED）3-十一烷基环己-2,5-二烯-1,2,4,5-四醇进行了分析。MED分别与乙酰胆碱酯酶（AChE）和淀粉样β蛋白（Aβ）受体对接，蛋白质数据银行（PDB）ID分别为1EVE和1B68。对接分数与阳性对照加兰他敏和多奈哌齐的相似。
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