Laboratory APERE, University de Picardie Jules Verne, Avenue Paul Claudel, 80000, Amiens, France.
B3OA Laboratory, CNRS 7052, INSERM 1271, University of Paris, 10 Avenue de Verdun, 75010, Paris, France.
Eur J Appl Physiol. 2024 Mar;124(3):761-773. doi: 10.1007/s00421-023-05293-2. Epub 2023 Sep 10.
It is now well established that physical exercise is an effective preventive method to reduce and treat certain chronic diseases, particularly musculoskeletal disorders. At the bone level, running exercise is well known for its positive effects on various parameters of bone quality. There is, however, no consensus regarding the effects of different running exercise modalities on bone quality.
The objective of this study was to compare the effects of three treadmill running modalities: intermittent, moderate continuous, and a combination of both-on bone quality parameters in rats.
Thirty-nine, 5-week-old, male Wistar rats were randomly divided in 4 groups: sedentary control (SED; n = 10), intermittent running exercise (IE; n = 10), continuous running exercise (CE; n = 10) and combined running exercise (COME; n = 9). Rats in running groups were exercised 45 min/day, 5 days/week, for 8 consecutive weeks. Femoral micro-architectural parameters were assessed by micro-CT; femoral osteocyte apoptosis, osteoclast resorption and bone histomorphometry were assessed by histology.
Femoral trabecular thickness in the combined running group was increased (p < 0.0001) compared to respective results in the other running groups (0.13 mm vs 0.11 mm). The cortical thickness, osteocyte lacunae occupancy rate in the whole femur, numbers of apoptotic osteocytes and osteoclastic resorption surfaces were not significantly different between groups. Statistical differences were occasionally noted depending on the femoral anatomical region.
These results suggest that the femur should not be considered as the better bone to study the effects of running protocols.
运动锻炼是一种有效预防手段，可以降低和治疗某些慢性疾病，尤其是肌肉骨骼疾病。在骨骼水平上，跑步运动已被证明对各种骨质量参数具有积极影响。然而，对于不同的跑步运动方式对骨质量的影响，目前尚无共识。
本研究旨在比较三种跑步机跑步方式（间歇跑、中速持续跑和混合跑）对大鼠骨质量参数的影响。
39 只 5 周龄雄性 Wistar 大鼠被随机分为 4 组：安静对照组（SED；n = 10）、间歇跑运动组（IE；n = 10）、持续跑运动组（CE；n = 10）和混合跑运动组（COME；n = 9）。跑步组大鼠每天运动 45 分钟，每周 5 天，连续 8 周。通过 micro-CT 评估股骨微结构参数；通过组织学评估股骨破骨细胞凋亡、破骨细胞吸收和骨组织形态计量学。
与其他跑步组相比（0.11mm），联合跑步组的股骨小梁厚度增加（p < 0.0001）（0.13mm）。全股骨皮质厚度、骨细胞腔隙占有率、凋亡骨细胞数量和破骨细胞吸收表面无明显差异。在股骨解剖区域方面，偶尔会注意到统计学差异。
这些结果表明，股骨不应被视为研究跑步方案影响的更好的骨骼部位。
