Fontes Elizabeth P B
Biochemistry and Molecular Biology Department, Bioagro, Universidade Federal de Viçosa, 36570.000, Viçosa, MG, Brazil.
Curr Opin Plant Biol. 2024 Feb;77:102447. doi: 10.1016/j.pbi.2023.102447. Epub 2023 Sep 8.
SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES (SERKs) and NUCLEAR SHUTTLE PROTEIN-INTERACTING KINASES (NIKs) belong to superfamily II of leucine-rich repeat receptor-like kinases, which share cytosolic kinase conservation and a similar ectodomain configuration. SERKs have been extensively demonstrated to function as coreceptors of receptor-like kinases, which sense biotic or developmental signals to initiate specific responses. NIKs, on the other hand, have emerged as downstream components in signaling cascades, not functioning as coreceptors but rather serving as hubs that converge information from both biotic and abiotic signals, resulting in a unified response. Like SERKs, NIKs play a crucial role as information spreaders in plant cells, forming hubs of high centrality. However, unlike SERKs, which function as coreceptors and assemble paired receptor-specific responses, NIKs employ a shared signaling circuit to transduce diverse biotic and abiotic signals into the same physiological response. Therefore, this review highlights the concept of signaling hubs that differ from coreceptors in signaling pathways.
体细胞胚胎发生受体类激酶（SERKs）和核穿梭蛋白相互作用激酶（NIKs）属于富含亮氨酸重复序列受体类激酶的超家族II，它们具有胞质激酶保守结构和相似的胞外结构域构型。SERKs已被广泛证明作为受体类激酶的共受体发挥作用，这些受体类激酶感知生物或发育信号以启动特定反应。另一方面，NIKs已成为信号级联反应中的下游组分，它们不作为共受体发挥作用，而是作为汇集来自生物和非生物信号信息的枢纽，从而产生统一的反应。与SERKs一样，NIKs在植物细胞中作为信息传播者发挥关键作用，形成高度中心性的枢纽。然而，与作为共受体并组装成对的受体特异性反应的SERKs不同，NIKs采用共享的信号传导回路将多种生物和非生物信号转导为相同的生理反应。因此，本综述强调了信号枢纽这一概念，其在信号通路中不同于共受体。
