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3-甲基胆蒽诱导的小鼠胸腺瘤中c-K-ras激活的高频率

High frequency of c-K-ras activation in 3-methylcholanthrene-induced mouse thymomas.

作者信息

Eva A, Trimmer R W

出版信息

Carcinogenesis. 1986 Nov;7(11):1931-3. doi: 10.1093/carcin/7.11.1931.

DOI:10.1093/carcin/7.11.1931
PMID:3769142
Abstract

Thymic lymphomas were induced in RJF mice by percutaneous application of 3-methylcholanthrene (MCA). DNAs from 83% of the tumors analyzed contained a transforming c-K-ras gene. The high frequency of c-K-ras oncogene activation in response to MCA seems to favor the concept that the activation of c-K-ras is related to the specificity of the mutagenic effect of MCA.

摘要

通过经皮涂抹3-甲基胆蒽（MCA）在RJF小鼠中诱发胸腺淋巴瘤。分析的肿瘤中83%的DNA含有转化型c-K-ras基因。对MCA产生反应时c-K-ras癌基因激活的高频率似乎支持这样一种观点，即c-K-ras的激活与MCA诱变作用的特异性有关。

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