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3-甲基胆蒽诱导的BALB/c纤维肉瘤中激活的c-K-ras和c-N-ras癌基因

Activated c-K-ras and c-N-ras oncogenes in 3-methylcholanthrene-induced BALB/c fibrosarcomas.

作者信息

Borrello M G, Carbone G, Pierotti M A, Molla A, Della Porta G

机构信息

Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.

出版信息

Carcinogenesis. 1988 Aug;9(8):1517-9. doi: 10.1093/carcin/9.8.1517.

DOI:10.1093/carcin/9.8.1517
PMID:3402050
Abstract

DNAs from fourteen fibrosarcomas induced by 3-methylcholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K-ras and two c-N-ras. These results demonstrate that c-K-ras is not the only oncogene of the ras family activated in MCA-induced murine fibrosarcomas as was previously indicated.

摘要

对由3-甲基胆蒽（MCA）诱导BALB/c小鼠产生的14个纤维肉瘤的DNA进行分析，以检测转染至NIH3T3细胞后转化癌基因的存在情况。6个转染阳性的DNA含有激活的ras基因：4个c-K-ras和2个c-N-ras。这些结果表明，c-K-ras并非如之前所指出的那样，是MCA诱导的小鼠纤维肉瘤中唯一被激活的ras家族癌基因。

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引用本文的文献

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Tumorigenic methylcholanthrene transformants of C3H/10T1/2 cells have a common nucleotide alteration in the c-Ki-ras gene.C3H/10T1/2细胞的致瘤性甲基胆蒽转化体在c-Ki-ras基因中存在一个共同的核苷酸改变。
Proc Natl Acad Sci U S A. 1989 Mar;86(5):1608-11. doi: 10.1073/pnas.86.5.1608.