Palupi Satiti, Chongsuvivatwong Virasakdi, Surya Asik, Suyanto Suyanto, Kumwichar Ponlagrit
Department of Epidemiology, Prince of Songkla University, Hat Yai, THA.
Department of Communicable Disease, East Java Provincial Health Office, Surabaya, IDN.
Cureus. 2023 Sep 7;15(9):e44857. doi: 10.7759/cureus.44857. eCollection 2023 Sep.
Tuberculosis (TB) and COVID-19 are highly transmissible diseases and pose a serious risk to public health. Unfortunately, information on cross-risk between the two diseases was still sparse. Our main objective was to estimate the excess risk among TB patients in getting COVID-19 infection and vice versa.
The study design was a series of analyses of existing data from TB and COVID-19 registries in East Java Province, Indonesia. The study period was from January 2020 to June 2022. Case-by-case data for this study were obtained from the registration systems for TB and COVID-19 in separate databases. In comparing risk across different groups, adjusting for differences in risk factors that influence the outcome was essential. We overcame this problem by employing a standardized morbidity ratio.
Among 92,424 newly diagnosed TB patients, 1,326 were subsequently infected with COVID-19 during the study period, compared with 1,679 expected. The standardized morbidity ratio (95% confidence interval) was 72.61% (60.19%, 85.03%). Among 635,946 newly diagnosed COVID-19-infected patients, 987 subsequently got active TB during the study period against 1,679 expected. The standardized morbidity ratio (95% confidence interval) was 55.33% (49.24%, 61.42%).
There was no evidence of excess risk in either direction, the excess risk among TB patients in getting COVID-19 infection and vice versa.
结核病（TB）和2019冠状病毒病（COVID-19）是高传染性疾病，对公众健康构成严重风险。不幸的是，关于这两种疾病交叉风险的信息仍然稀少。我们的主要目标是估计结核病患者感染COVID-19的额外风险，反之亦然。
本研究设计是对印度尼西亚东爪哇省结核病和COVID-19登记处的现有数据进行一系列分析。研究期间为2020年1月至2022年6月。本研究的逐案数据来自单独数据库中结核病和COVID-19的登记系统。在比较不同组的风险时，调整影响结果的风险因素差异至关重要。我们通过采用标准化发病率来克服这个问题。
在92424例新诊断的结核病患者中，有1326例在研究期间随后感染了COVID-19，而预期为1679例。标准化发病率（95%置信区间）为72.61%（60.19%，85.03%）。在635946例新诊断的COVID-19感染患者中，有987例在研究期间随后患上活动性结核病，而预期为1679例。标准化发病率（95%置信区间）为55.33%（49.24%，61.42%）。
没有证据表明存在任何一个方向的额外风险，即结核病患者感染COVID-19的额外风险以及反之亦然。
