Vítková L, Kazantseva N, Musilová L, Smolka P, Valášková K, Kocourková K, Humeník M, Minařík A, Humpolíček P, Mráček A, Smolková I
Faculty of Technology, Tomas Bata University in Zlin, Vavrečkova 5669, 76001 Zlín, Czech Republic.
Centre of Polymer Systems, Tomas Bata University in Zlin, tř. Tomáše Bati 5678, 76001 Zlín, Czech Republic.
APL Bioeng. 2023 Sep 7;7(3):036113. doi: 10.1063/5.0147181. eCollection 2023 Sep.
Magneto-responsive soft hydrogels are used for a number of biomedical applications, e.g., magnetic hyperthermia, drug delivery, tissue engineering, and neuromodulation. In this work, this type of hydrogel has been fabricated from hyaluronan (HA) filled with a binary system of AlO nanoparticles and multicore magnetic particles (MCPs), which were obtained by clustering of superparamagnetic iron oxide FeO NPs. It was established that the presence of diamagnetic AlO has several positive effects: it enhances the hydrogel storage modulus and long-term stability in the cell cultivation medium; prevents the magnetic interaction among the MCPs. The HA hydrogel provides rapid heating of 0.3 °C per min under exposure to low amplitude radio frequency alternating magnetic field. Furthermore, the magneto-responsive hydrogel was successfully used to encapsulate cells and extrusion-based 3D printing with 87±6% cell viability, thus providing a bio-ink. The combination of high heating efficiency, softness, cytocompatibility, and 3D printability of magnetic HA hydrogel leads to a material suitable for biomedical applications.
磁响应性软水凝胶被用于多种生物医学应用，例如磁热疗、药物递送、组织工程和神经调节。在这项工作中，这种类型的水凝胶由填充有AlO纳米颗粒和多核磁性颗粒（MCPs）二元体系的透明质酸（HA）制成，其中多核磁性颗粒是通过超顺磁性氧化铁FeO NPs聚集获得的。已确定抗磁性AlO的存在有几个积极作用：它提高了水凝胶的储能模量以及在细胞培养基中的长期稳定性；防止了MCPs之间的磁性相互作用。HA水凝胶在低振幅射频交变磁场作用下能以每分钟0.3 °C的速度快速升温。此外，磁响应性水凝胶成功用于封装细胞，并通过基于挤出的3D打印实现了87±6%的细胞活力，从而提供了一种生物墨水。磁性HA水凝胶的高加热效率、柔软性、细胞相容性和3D可打印性相结合，产生了一种适用于生物医学应用的材料。
