Suksanga Anunya, Siripongvutikorn Sunisa, Leelawattana Rattana, Yupanqui Chutha T
Functional Food and Nutrition Program, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Songkhla, Thailand.
Center of Excellence in Functional Foods and Gastronomy, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Songkhla, Thailand.
J Nutr Metab. 2023 Aug 31;2023:5630204. doi: 10.1155/2023/5630204. eCollection 2023.
Chlorophyll and chlorophyllin (CHL) demonstrated antidiabetic activity by inhibiting gluconeogenesis and increasing glucose uptake in rats' muscle cells. Liang leaves contain high amounts of chlorophyll and chlorophyllin and may provide an antidiabetic effect. The antidiabetic activity of chlorophyll and CHL contained in Liang leaves, Cu-chlorophyllin (CCL) Liang leaves treated with CuSO, and untreated crude Liang leaves (CLL) were compared using commercial chlorophyllin (CHL) as a reference. Twelve Wistar male rats were separated into 4 groups (3 rats/group); the first was a normal one (based line group), the second were the diabetic rats treated with CHL, while the third and the fourth were the diabetic rats treated with 0.97 g/kg of CCL and CLL, respectively. Diabetic rats were induced by a high fructose diet, before being taken to administer commercial CHL, CCL, and CLL for 7 days. Nonfasting blood glucose and body weight were checked daily. After euthanasia, organ weight, biochemical, hematological, and histopathological properties were evaluated. CCL treatment showed no antihyperglycemic activity in the rat model but caused some biochemical abnormalities and thrombocytopenia. Commercial CHL gave a higher reduction of nonfasting blood glucose (NFBG) than Liang leaves powder CCL or CLL but also showed some signs of abnormal biochemical parameters. CLL exhibited an antihyperglycemic effect, with higher body weight and increased HDL/LDL ratio and thus could be a promising alternative natural source for diabetes treatment.
叶绿素和叶绿酸（CHL）通过抑制糖异生和增加大鼠肌肉细胞对葡萄糖的摄取表现出抗糖尿病活性。梁叶含有大量的叶绿素和叶绿酸，可能具有抗糖尿病作用。以市售叶绿酸（CHL）为对照，比较了梁叶中所含叶绿素和CHL、经硫酸铜处理的铜叶绿酸（CCL）梁叶以及未处理的粗梁叶（CLL）的抗糖尿病活性。将12只雄性Wistar大鼠分为4组（每组3只）；第一组为正常组（基线组），第二组为用CHL治疗的糖尿病大鼠，第三组和第四组分别为用0.97 g/kg CCL和CLL治疗的糖尿病大鼠。通过高果糖饮食诱导糖尿病大鼠，然后分别给予市售CHL、CCL和CLL 7天。每天检查非空腹血糖和体重。安乐死后，评估器官重量、生化、血液学和组织病理学特性。CCL治疗在大鼠模型中未显示出降血糖活性，但导致了一些生化异常和血小板减少。市售CHL比梁叶粉末CCL或CLL能更有效地降低非空腹血糖（NFBG），但也显示出一些生化参数异常的迹象。CLL表现出降血糖作用，体重增加，HDL/LDL比值升高，因此可能是一种有前途的糖尿病治疗天然替代来源。
