Y Dinesh, Ramani Pratibha, Yuwanati Monal, Ramalingam Karthikeyan, S Gheena
Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2023 Aug 9;15(8):e43235. doi: 10.7759/cureus.43235. eCollection 2023 Aug.
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer with several risk factors. Exosomes are extracellular vesicles generated by the fusion of multivesicular structures with the cell membrane and play an important role as intercellular messengers. MicroRNA (miRNA) is a noncoding RNA and regulates post-transcriptional modification. The present systematic review aims to identify and correlate the possible association and role of circulating exosomes with OSCC. Using the search strategy, articles fulfilling the inclusion criteria, published between January 2012 to March 2022, were retrieved from online databases including PubMed, Scopus, Web of Science, and Cochrane Library. About 904 articles were found using an electronic database and a human search. After reviewing the titles and abstracts, 614 studies were eliminated, and duplicate articles were removed. Five studies were included in this systematic review. Circulating exosomal expression of miRNA27, miRNA 21, and miRNA 155 showed significant upregulation in OSCC patients. Circulating exosomes could be potential biomarkers to be used in the detection of patients with OSCC. More studies are warranted in this area to gain a better understanding of the pathophysiology of OSCC and the function of molecular markers from circulating exosomes. Understanding the role of molecular markers from circulating exosomes in pathogenesis will provide a better understanding of the development of the disease, necessitating more study in this area. According to this review, circulating exosomes might be a potential approach to the identification of OSCC.
口腔鳞状细胞癌（OSCC）是最常见的头颈癌，存在多种风险因素。外泌体是多泡体结构与细胞膜融合产生的细胞外囊泡，作为细胞间信使发挥着重要作用。微小RNA（miRNA）是一种非编码RNA，可调节转录后修饰。本系统综述旨在确定循环外泌体与OSCC之间可能的关联和作用，并进行相关性分析。采用检索策略，从包括PubMed、Scopus、科学网和考克兰图书馆在内的在线数据库中检索2012年1月至2022年3月期间发表的符合纳入标准的文章。通过电子数据库检索和人工检索共找到约904篇文章。在审阅标题和摘要后，排除了614项研究，并剔除了重复文章。本系统综述纳入了5项研究。miRNA27、miRNA 21和miRNA 155的循环外泌体表达在OSCC患者中显著上调。循环外泌体可能是用于检测OSCC患者的潜在生物标志物。该领域有必要开展更多研究，以更好地了解OSCC的病理生理学以及循环外泌体中分子标志物的功能。了解循环外泌体中的分子标志物在发病机制中的作用将有助于更好地理解该疾病的发展，因此该领域需要更多研究。根据本综述，循环外泌体可能是识别OSCC的一种潜在方法。
