Zeng Bingjie, Wang Xianzhao, Qin Yueyang, Cao Leiqun, Zhang Congcong, Meng Fanyu, Chen Changqiang, Wang Jiayi, Ma Lifang
Department of Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Health Sci Rep. 2023 Sep 8;6(9):e1522. doi: 10.1002/hsr2.1522. eCollection 2023 Sep.
Lung cancer incidence and mortality remain high and are now the leading cause of cancer-related death. Lung adenocarcinoma (LUAD) is one of the main histological subtypes of lung cancer. Previous studies have shown the role of inflammation in the development of lung cancer, but the relationship between cytokines and LUAD is still unclear. To further differentiate and explore the association of cytokines with the risk of non-invasive and invasive LUAD, we studied and assessed serum cytokine levels in patients with two types of LUAD.
A cohort study of 90 non-invasive LUAD and 90 invasive LUAD was retrospectively included, and the clinical characteristics were recorded in detail. The differences in the levels of 12 serum cytokines (IFN-α, IFN-γ, IL-10, IL-12P70, IL-17A, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, and TNF-α) between the two groups of patients with LUAD were analyzed and evaluated. And we evaluated the clinical value of cytokine differential diagnosis of invasive LUAD based on receiver operating characteristics (ROC) curves.
The mean age of the patients was 56.6 years, and the proportions of males and females were 38.9% and 61.1%, respectively. IFN-α, IL-1β, IL-2, IL-6, TNF-α, IL-4, and IL-8 were significantly increased in patients with invasive LUAD compared with the non-invasive LUAD group. Further research found that smoking is an important factor, with changes in the four cytokines IL-1β, IL-6, IL-8, and TNF-α being significantly higher in the smoking group of patients with invasive LUAD. It can be seen from the area under the curve that IL-1β and IL-2 have a significant differential diagnosis.
We observed differences in preoperative serum cytokine levels between patients with invasive and non-invasive LUAD, which may serve as potential serum biomarkers for clinical differential diagnosis and disease progression assessment.
肺癌的发病率和死亡率仍然很高，目前是癌症相关死亡的主要原因。肺腺癌（LUAD）是肺癌的主要组织学亚型之一。先前的研究已经表明炎症在肺癌发展中的作用，但细胞因子与LUAD之间的关系仍不清楚。为了进一步区分和探索细胞因子与非侵袭性和侵袭性LUAD风险的关联，我们研究并评估了两种类型LUAD患者的血清细胞因子水平。
回顾性纳入了一项对90例非侵袭性LUAD和90例侵袭性LUAD的队列研究，并详细记录了临床特征。分析并评估了两组LUAD患者之间12种血清细胞因子（IFN-α、IFN-γ、IL-10、IL-12P70、IL-17A、IL-1β、IL-2、IL-4、IL-5、IL-6、IL-8和TNF-α）水平的差异。并且我们基于受试者工作特征（ROC）曲线评估了细胞因子对侵袭性LUAD的鉴别诊断的临床价值。
患者的平均年龄为56.6岁，男性和女性的比例分别为38.9%和61.1%。与非侵袭性LUAD组相比，侵袭性LUAD患者的IFN-α、IL-1β、IL-2、IL-6、TNF-α、IL-4和IL-8显著升高。进一步研究发现吸烟是一个重要因素，侵袭性LUAD患者吸烟组中四种细胞因子IL-1β、IL-6、IL-8和TNF-α的变化明显更高。从曲线下面积可以看出，IL-1β和IL-2具有显著的鉴别诊断价值。
我们观察到侵袭性和非侵袭性LUAD患者术前血清细胞因子水平存在差异，这可能作为临床鉴别诊断和疾病进展评估的潜在血清生物标志物。
