Zhang Bin, Wang Xiaoxia
Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University Tai'an, Shandong, China.
Department of Hematology and Oncology, The First People's Hospital of Tai'an Tai'an, Shandong, China.
Am J Transl Res. 2023 Aug 15;15(8):5495-5507. eCollection 2023.
To analyze the mortality trend of ischemic heart disease (IHD) attributed to particulate matter (PM) 2.5 exposure among Chinese populations from 1990 to 2019. To evaluate the influences of cohort, period, and age on long-term of IHD mortality trends.
Global burden of disease (GBD) data in 2019 regarding IHD death rate attributed to exposure to (PM) 2.5 in China from 1990 to 2019 were adopted. The age-period-cohort (APC) model based on the R language produced by the National Cancer Institute of the United States was used for statistical analysis to investigate the influences of different ages, periods, and cohorts on IHD death rate attributed to exposure to (PM) 2.5.
The age-standardized death rate of IHD attributed to exposure to ambient (PM) 2.5 in China revealed an uptrend from 1990 to 2019. This increased from 8.63/100,000 in 1990 to 21.31/100,000 in 2019. This was an increase of 1.47%. The age-standardized IHD death rate attributed to exposure to household (PM) 2.5 showed a decreasing trend. This decreased from 19.61/100,000 in 1990 to 8.72/100,000 in 2019. This was a decrease of 0.74%. The results of the APC model indicated that the annual net drift of IHD mortality attributed to exposure to (PM) 2.5 was -0.10%. The annual net drifts of exposure to household and ambient (PM) 2.5 were -4.54% and 3.44%, respectively. The IHD death rate attributed to ambient and household (PM) 2.5 exposure in the same birth cohort enhanced with age. With time, the rate ration (RR) of period effects of IHD mortality attributed to ambient (PM) 2.5 exposure for both male and female showed an upward trend. The RR of period effects of IHD death rate attributed to household (PM) 2.5 exposure suggested a downtrend. In the consecutive birth cohorts, the population in China with a later birth cohort presented a higher risk of IHD death attributed to exposure to ambient (PM) 2.5 and a lower risk of IHD death attributed to household (PM) 2.5 exposure.
In China for the burden of IHD attributed to exposure to (PM) 2.5, the primary environmental risk was ambient (PM) 2.5 exposure compared to exposure to household PM2.5. IHD exposure to environmental air pollution posed a greater risk to young people.
分析1990年至2019年中国人群中因暴露于细颗粒物（PM）2.5导致的缺血性心脏病（IHD）死亡率趋势。评估队列、时期和年龄对IHD死亡率长期趋势的影响。
采用2019年全球疾病负担（GBD）数据中关于1990年至2019年中国因暴露于（PM）2.5导致的IHD死亡率。使用美国国立癌症研究所基于R语言产生的年龄-时期-队列（APC）模型进行统计分析，以研究不同年龄、时期和队列对因暴露于（PM）2.5导致的IHD死亡率的影响。
中国因暴露于环境（PM）2.5导致的IHD年龄标准化死亡率在1990年至2019年呈上升趋势。从1990年的8.63/10万增加到2019年的21.31/10万。增长了1.47%。因暴露于家庭（PM）2.5导致的IHD年龄标准化死亡率呈下降趋势。从1990年的19.61/10万下降到2019年的8.72/10万。下降了0.74%。APC模型结果表明，因暴露于（PM）2.5导致的IHD死亡率的年度净漂移为-0.10%。暴露于家庭和环境（PM）2.5的年度净漂移分别为-4.54%和3.44%。同一出生队列中因暴露于环境和家庭（PM）2.5导致的IHD死亡率随年龄增加。随着时间推移，男性和女性因暴露于环境（PM）2.5导致的IHD死亡率的时期效应率比（RR）呈上升趋势。因暴露于家庭（PM）2.5导致的IHD死亡率的时期效应RR呈下降趋势。在连续出生队列中，中国出生队列较晚的人群因暴露于环境（PM）2.5导致IHD死亡的风险较高，而因暴露于家庭（PM）2.5导致IHD死亡的风险较低。
在中国，对于因暴露于（PM）2.5导致的IHD负担，与暴露于家庭PM2.5相比，主要环境风险是暴露于环境（PM）2.5。IHD暴露于环境空气污染对年轻人构成更大风险。
