Xiao Guohu, Weng Minjie, Wang Ping
Department of Surgical, Hangzhou Lin'an District Hospital of Traditional Chinese Medicine Hangzhou 311300, Zhejiang, China.
Operating Room, Hangzhou Lin'an District Hospital of Traditional Chinese Medicine Hangzhou 311300, Zhejiang, China.
Am J Transl Res. 2023 Aug 15;15(8):5267-5275. eCollection 2023.
To analyze the effects of transcutaneous electrical nerve stimulation (TENS) combined with levofloxacin (0.1 g, twice daily) and tamsulosin (0.2 mg, once daily) on clinical efficacy and serum factors in patients with chronic prostatitis (CP).
A retrospective analysis was conducted on 105 patients with CP who received treatment at Hangzhou Lin'an District Hospital of Traditional Chinese Medicine from February 2020 to December 2022. Among them, 47 patients received levofloxacin and tamsulosin were included in a drug group (DG), and 58 patients received additional TENS therapy (frequency: 1/4/1 Hz+80/120/80 Hz; pulse width: 270/230/270 μs+120/80/120 μs; waveform: square and continuous waveforms) were included in a joint group (JG). The changes in the National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), international prostate symptom score (IPSS), and the levels of inflammatory and pain-causing factors were compared between the two groups before and after treatment. The clinical efficacy was compared between the two groups after treatment. Moreover, the incidence of adverse reactions was compared between the two groups.
After treatment, the scores of NIH-CPSI and IPSS, and the levels of IL-6, CRP, TNF-α, IL-1β, 5-hydroxytryptamine, substance P, and dynorphin in the JG were obviously lower than those in the DG (P<0.001). The clinical response rate in the DG was obviously lower than that in the JG (P=0.006, Table 2). There was no difference in total incidence of adverse reactions between the two groups (P=0.801).
Compared to medication alone (levofloxacin and tamsulosin), the combination of TENS with levofloxacin and tamsulosin can reduce the levels of inflammatory and pain-causing factors in patients, and improve the efficacy. Importantly, it has been observed that this combination therapy does not lead to an increase in adverse reactions and is considered to be safe for patients.
分析经皮电刺激神经疗法（TENS）联合左氧氟沙星（0.1克，每日两次）和坦索罗辛（0.2毫克，每日一次）对慢性前列腺炎（CP）患者临床疗效及血清因子的影响。
对2020年2月至2022年12月在杭州市临安区中医院接受治疗的105例CP患者进行回顾性分析。其中，47例接受左氧氟沙星和坦索罗辛治疗的患者纳入药物组（DG），58例接受额外TENS治疗（频率：1/4/1赫兹 + 80/120/80赫兹；脉冲宽度：270/230/270微秒 + 120/80/120微秒；波形：方波和连续波）的患者纳入联合组（JG）。比较两组治疗前后美国国立卫生研究院慢性前列腺炎症状指数（NIH - CPSI）、国际前列腺症状评分（IPSS）以及炎症和致痛因子水平的变化。比较两组治疗后的临床疗效。此外，比较两组不良反应的发生率。
治疗后，JG组的NIH - CPSI和IPSS评分以及IL - 6、CRP、TNF -α、IL - 1β、5 -羟色胺、P物质和强啡肽水平明显低于DG组（P < 0.001）。DG组的临床有效率明显低于JG组（P = 0.006，表2）。两组不良反应总发生率无差异（P = 0.801）。
与单纯药物治疗（左氧氟沙星和坦索罗辛）相比，TENS联合左氧氟沙星和坦索罗辛可降低患者炎症和致痛因子水平，提高疗效。重要的是，观察到这种联合治疗不会导致不良反应增加，对患者来说是安全的。
