Zhang Jun, Wang Peiqi, Li Yanzhi, Wu Jie
School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Chem Commun (Camb). 2023 Mar 28;59(26):3821-3826. doi: 10.1039/d2cc06339e.
Enantiomerically enriched sulfones occupy a prominent position in pharmaceutical chemistry and synthetic chemistry. Compared with conventional methods, a direct asymmetric sulfonylation reaction with the fixation of sulfur dioxide represents an attractive strategy for the rapid assembly of chiral sulfones with enantiopurity. In this highlight, we survey recent exciting advances in asymmetric sulfonylation by using sulfur dioxide surrogates, and discuss asymmetric induction modes, reaction mechanisms, substrate scope and opportunities for further studies.
对映体富集的砜类化合物在药物化学和合成化学中占据重要地位。与传统方法相比，利用二氧化硫固定的直接不对称磺酰化反应是一种快速构建具有对映体纯度的手性砜的有吸引力的策略。在本综述中，我们概述了使用二氧化硫替代物进行不对称磺酰化反应的最新进展，并讨论了不对称诱导模式、反应机理、底物范围以及进一步研究的机会。
