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给患有子宫内膜异位症的食蟹猴注射脐带间充质干细胞的影响。

Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis.

作者信息

Tsuji Shunichiro, Mukai Takeo, Tsuchiya Hideaki, Iwatani Chizuru, Nakamura Akiko, Nagamura-Inoue Tokiko, Murakami Takashi

机构信息

Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan.

Department of Pediatrics The University of Tokyo Hospital Bunkyo-ku, Tokyo Japan.

出版信息

Reprod Med Biol. 2023 Sep 8;22(1):e12540. doi: 10.1002/rmb2.12540. eCollection 2023 Jan-Dec.

DOI:10.1002/rmb2.12540
PMID:37693240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10491929/
Abstract

PURPOSE

This study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis.

METHODS

Of seven cynomolgus monkeys with endometriosis, five were administered UC-MSCs (intervention group) and two were administered saline (control group). First, intravenous US-MSC treatment was administered for three months. Second, weekly intravenous US-MSC administration combined with monthly intraperitoneal US-MSC administration was conducted for 3 months. Finally, weekly intraperitoneal US-MSC administration was conducted for 3 months. The dose of UC-MSCs was set to 2 × 10 cells/kg for all administration routes. Laparoscopic findings and serum cancer antigen 125 (CA125) levels were also evaluated. The Revised American Society for Reproductive Medicine classification was used for laparoscopic evaluation.

RESULTS

Laparoscopic findings showed exacerbation of endometriosis after intraperitoneal UC-MSC administration, although no changes were observed in the control group. Intravenous UC-MSC administration decreased the level of CA125 in all monkeys; however, the difference was not significant. Intraperitoneal UC-MSC administration significantly exacerbated endometriosis compared with intravenous administration ( = 0.02).

CONCLUSIONS

This study revealed that intraperitoneal UC-MSC administration exacerbates endometriosis in a nonhuman primate model of the disease.

摘要

目的

本研究旨在探讨脐带间充质干细胞（UC-MSCs）是否可作为子宫内膜异位症的一种治疗资源。

方法

在7只患有子宫内膜异位症的食蟹猴中，5只接受UC-MSCs治疗（干预组），2只接受生理盐水治疗（对照组）。首先，进行为期3个月的静脉注射UC-MSCs治疗。其次，每周进行静脉注射UC-MSCs并每月进行腹腔注射UC-MSCs，持续3个月。最后，每周进行腹腔注射UC-MSCs，持续3个月。所有给药途径的UC-MSCs剂量均设定为2×10⁶细胞/千克。还评估了腹腔镜检查结果和血清癌抗原125（CA125）水平。采用修订后的美国生殖医学学会分类法进行腹腔镜评估。

结果

腹腔镜检查结果显示，腹腔注射UC-MSCs后子宫内膜异位症加重，而对照组未观察到变化。静脉注射UC-MSCs使所有猴子的CA125水平降低；然而，差异不显著。与静脉注射相比，腹腔注射UC-MSCs显著加重了子宫内膜异位症（P = 0.02）。

结论

本研究表明，在该疾病的非人灵长类动物模型中，腹腔注射UC-MSCs会加重子宫内膜异位症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/a618c35eaed5/RMB2-22-e12540-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/3d35e0ea4baf/RMB2-22-e12540-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/2ec45d3f1774/RMB2-22-e12540-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/472d96aca73f/RMB2-22-e12540-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/7a7c65af2dc0/RMB2-22-e12540-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/a618c35eaed5/RMB2-22-e12540-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/3d35e0ea4baf/RMB2-22-e12540-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/2ec45d3f1774/RMB2-22-e12540-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/472d96aca73f/RMB2-22-e12540-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/7a7c65af2dc0/RMB2-22-e12540-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf1c/10491929/a618c35eaed5/RMB2-22-e12540-g004.jpg

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