Villanueva-Meyer J, Marcus C, Thompson K, Philippe L, Mena I
Clin Nucl Med. 1986 Feb;11(2):88-91. doi: 10.1097/00003072-198602000-00005.
The diagnosis of a pulmonary arteriovenous malformation (AVM) was made by performing a computer-assisted first-pass cardiopulmonary imaging procedure using Tc-99m pertechnetate and processing the image information using factor analysis. This analytical technique is capable of separating partially overlapping structures by automatically extracting factors with different temporal behavior (time-activity curves) which correspond to functional areas without anatomic constraint. This procedure was accomplished successfully despite the presence of four-chamber enlargement, mitral stenosis and regurgitation, tricuspid regurgitation, chronic obstructive pulmonary disease and pulmonary hypertension. The magnitude of the right-to-left shunt resulting from the AVM was quantitated using both the factor analysis data and an independent Tc-99m MAA computer-assisted imaging procedure. Both methods gave comparable values.
通过使用锝-99m高锝酸盐进行计算机辅助首次通过心肺成像程序，并使用因子分析处理图像信息，诊断出肺动静脉畸形（AVM）。这种分析技术能够通过自动提取具有不同时间行为（时间-活性曲线）的因子来分离部分重叠的结构，这些因子对应于无解剖学限制的功能区域。尽管存在四腔扩大、二尖瓣狭窄和反流、三尖瓣反流、慢性阻塞性肺疾病和肺动脉高压，该程序仍成功完成。使用因子分析数据和独立的锝-99m大颗粒聚合人血清白蛋白计算机辅助成像程序对由AVM导致的右向左分流的大小进行了定量。两种方法给出了可比的值。
