Shih W J, Coupal J J, DeLand F H, Domstad P A, Brandenburg S, Dillon M L
Clin Nucl Med. 1986 Sep;11(9):632-3. doi: 10.1097/00003072-198609000-00008.
A patient whose huge lung mass was demonstrated as a large defect on I-123 N,N,N'trimethyl-N'[2-hydroxy-3-methyl-5-iodobenzyl]-1,3-propanediamine (HIPDM) lung imaging is presented. I-123 HIPDM, a lipophilic agent, is designed for early detection of abnormal cerebral perfusion. Since up to 50% of the administered agent is accumulated and perhaps metabolized in the lung, the radiopharmaceutical may be potentially useful for detection of pathology of the lung in addition to evaluation of pulmonary amine metabolism.
本文报告了一名患者，其巨大肺部肿块在 I-123 N，N，N'-三甲基-N'[2-羟基-3-甲基-5-碘苄基]-1,3-丙二胺（HIPDM）肺部显像中表现为一个大的缺损区。I-123 HIPDM 是一种亲脂性药物，设计用于早期检测异常脑灌注。由于高达 50%的给药药物会在肺部蓄积并可能代谢，除了评估肺胺代谢外，这种放射性药物可能对检测肺部病变也有潜在用途。
