Arora Priyanka, Mahapatra Madhushmita, Arora Kamaldeep
Department of Ophthalmology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1266-S1269. doi: 10.4103/jpbs.jpbs_130_23. Epub 2023 Jul 11.
To analyze the incidence of retinopathy of prematurity (ROP) among preterm neonates who were born small for gestational age (SGA) and appropriate for gestational age (AGA).
A prospective cohort study among preterm neonates born <34 weeks of gestational age (GA) and <2000 grams birth weight (BW) was conducted. The neonates were divided into AGA and SGA group. Incidence of ROP and risk factors was compared among the groups.
290 neonates were screened [AGA: 240 (82.8%); SGA: 50 (17.2%)]. The mean birth-weight and gestational age were 1510.7 ± 390.64 grams and 31.4 ± 4.8 weeks, respectively. The incidence of ROP in AGA and SGA was 30.2% and 33%, respectively ( = 0.58), whereas the incidence of type 1 ROP in AGA and SGA was 14% and 19% ( = 0.41). Male sex, anemia, oxygen administration, surfactant administration, sepsis, and PIH were independent significant risk factors for ROP on multivariate analysis.
This study showed that both AGA and SGA premature infants have similar incidence of ROP. SGA is not an independent risk factor for ROP.
分析小于胎龄儿（SGA）和适于胎龄儿（AGA）早产新生儿的早产儿视网膜病变（ROP）发病率。
对孕周小于34周（GA）且出生体重（BW）小于2000克的早产新生儿进行前瞻性队列研究。将新生儿分为AGA组和SGA组。比较两组间ROP发病率及危险因素。
共筛查290例新生儿[AGA组：240例（82.8%）；SGA组：50例（17.2%）]。平均出生体重和孕周分别为1510.7±390.64克和31.4±4.8周。AGA组和SGA组的ROP发病率分别为30.2%和33%（P=0.58），而AGA组和SGA组1型ROP的发病率分别为14%和19%（P=0.41）。多因素分析显示，男性、贫血、吸氧、使用表面活性剂、败血症和妊娠高血压综合征是ROP的独立显著危险因素。
本研究表明，AGA和SGA早产儿的ROP发病率相似。SGA不是ROP的独立危险因素。
