Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
J Inflamm Res. 2014 May 29;7:69-87. doi: 10.2147/JIR.S63898. eCollection 2014.
Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitamin D status with increased risk and unfavorable outcome of acute infections. Vitamin D supplementation bolsters clinical responses to acute infection. Moreover, chronic inflammatory diseases, such as atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and others, tend to have lower vitamin D status, which may play a pleiotropic role in the pathogenesis of the diseases. In this article, we review recent epidemiological and interventional studies of vitamin D in various inflammatory diseases. The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are also discussed.
除了在钙稳态中发挥关键作用外，维生素 D 最近还被发现通过调节炎症细胞因子的产生和抑制促炎细胞的增殖，在调节免疫/炎症系统方面发挥着重要作用，这两者对于炎症性疾病的发病机制都至关重要。一些研究表明，维生素 D 水平较低与急性感染的风险增加和不良预后有关。维生素 D 补充可增强对急性感染的临床反应。此外，慢性炎症性疾病，如与动脉粥样硬化相关的心血管疾病、哮喘、炎症性肠病、慢性肾病、非酒精性脂肪肝疾病等，往往维生素 D 水平较低，这可能在疾病发病机制中发挥多种作用。本文综述了最近关于维生素 D 在各种炎症性疾病中的流行病学和干预性研究。还讨论了维生素 D 调节炎症性疾病中免疫/炎症反应的潜在机制。
