Izzo G, Favella A, Sposito S, Alfani D, Valeri L, Magrini A
Clin Phys Physiol Meas. 1986 Aug;7(3):211-24. doi: 10.1088/0143-0815/7/3/002.
Quantitative information on spleen perfusion may be obtained as a byproduct of liver studies using 99Tcm colloids, by means of model analysis of dynamic data collected with a large field-of-view computerized gamma camera for about 4 min after intravenous administration of the tracer. Spleen extraction efficiency, vascular transit time, and parameters related to spleen blood flow, splenic clearance and volume of distribution of the tracer were computed, the latter three being expressed in arbitrary units. Results in 14 normal subjects and 78 patients with liver cirrhosis show good agreement with known physiopathological data. Results in five splenectomised patients and one patient undergoing ligation of the splenic artery provided further confirmation of the physiopathological meaning of the estimated parameters. Accuracy was found to be poor for spleens of small (normal) size, but was acceptable for enlarged spleens. Reproducibility of the results appears to be within 20%. It is concluded that this method, when associated with the study of liver function using a single 3-4 mCi dose of radiocolloids, may provide valuable additional information for routine assessment of splanchnic haemodynamics in patients with portal hypertension and splenomegaly.
利用99锝胶体进行肝脏研究时，脾脏灌注的定量信息可作为副产品获得。方法是在静脉注射示踪剂后，使用大视野计算机γ相机收集约4分钟的动态数据，并进行模型分析。计算脾脏提取效率、血管通过时间以及与脾血流量、脾脏清除率和示踪剂分布容积相关的参数，后三项以任意单位表示。14名正常受试者和78例肝硬化患者的结果与已知的生理病理数据高度一致。5例脾切除患者和1例接受脾动脉结扎患者的结果进一步证实了所估计参数的生理病理意义。发现该方法对小（正常）尺寸脾脏的准确性较差，但对肿大脾脏的准确性尚可接受。结果的重现性似乎在20%以内。结论是，当与使用单一3 - 4毫居里放射性胶体的肝功能研究相结合时，该方法可为门静脉高压和脾肿大患者的内脏血流动力学常规评估提供有价值的额外信息。
