Blomley M J, Kormano M, Coulden R, Lim-Dunham J, Dawson P, Lipton M J
Department of Radiology, University of Chicago Hospitals, IL, USA.
Acad Radiol. 1997 Jan;4(1):13-20. doi: 10.1016/s1076-6332(97)80155-9.
To study splenic perfusion with use of computed tomography (CT).
Twenty-six control patients without splenoportal disease, six with cirrhosis, and seven with other splenic disease were examined with electron-beam CT. Twenty-five milliliters of iohexol (300 mg of iodine per milliliter) was given intravenously at 10 mL/sec followed by a saline bolus. Multiple single-level axial sections were acquired 8-90 seconds after injection. Perfusion was calculated by dividing maximal splenic enhancement by the area under the circulation-corrected aortic time-enhancement curve. Subjective assessments of enhancement heterogeneity were made, and regional perfusion was calculated in 10 patients with heterogeneous enhancement. Total splenic volume and blood flow were computed in 21 patients.
Mean perfusion (controls: 1.29 mL/min/mL, miscellaneous group: 1.07 mL/min/mL) was close to predictions. There was a trend toward lower perfusion in cirrhotic patients (0.87 mL/min/mL), but the difference was not statistically significant. Total splenic blood was increased in patients with cirrhosis (P < .01). Marked perfusion heterogeneity was observed in 41% of spleens, but by 2 minutes splenic enhancement was uniform.
CT shows promise in the study of splenic blood flow.
利用计算机断层扫描（CT）研究脾脏灌注情况。
对26例无脾门静脉疾病的对照患者、6例肝硬化患者及7例患有其他脾脏疾病的患者进行电子束CT检查。以10毫升/秒的速度静脉注射25毫升碘海醇（每毫升含300毫克碘），随后注入生理盐水冲管。注射后8至90秒获取多个单层轴向图像。灌注量通过将脾脏最大强化值除以经循环校正的主动脉时间 - 强化曲线下的面积来计算。对强化不均匀性进行主观评估，并对10例强化不均匀的患者计算局部灌注量。对21例患者计算脾脏总体积和血流量。
平均灌注量（对照组：1.29毫升/分钟/毫升，其他组：1.07毫升/分钟/毫升）接近预期。肝硬化患者的灌注量有降低趋势（0.87毫升/分钟/毫升），但差异无统计学意义。肝硬化患者的脾脏总血流量增加（P < 0.01）。41%的脾脏观察到明显的灌注不均匀性，但到2分钟时脾脏强化变得均匀。
CT在脾脏血流研究中显示出前景。
