Ghavi Fatemeh, Shakeri Fatemeh, Farahnaz Heshmat, Abdolahian Somayeh
Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Midwifery, School of Nursing and Midwifery, Jahrom University of Medical Sciences, Jahrom, Iran.
Iran J Nurs Midwifery Res. 2023 Jul 24;28(4):430-435. doi: 10.4103/ijnmr.ijnmr_149_22. eCollection 2023 Jul-Aug.
Using natural oral supplements is one of the methods of complementary medicine that has been widely welcomed in the last decade Since studies have reported contradictory results for effectiveness of herbal medicines during menopause and no other more effective herbal medicine has been suggested yet, the researchers of this study decided to compare the fennel and Evening Primrose Oil (EPO) and their effect on menopause problems and sex hormones.
The present study was a triple-blinded, controlled clinical trial with 125 participants randomly assigned to. An intervention group received fennel, another intervention group received evening primrose oil, and the placebo group received placebo twice daily for 8 weeks. Pre-intervention and post-intervention results were obtained using hormonal assay and the Menopause Rating Scale (MRS).
In this study, the mean follicle-stimulating hormone (FSH) and estradiol levels changed significantly in the fennel and EPO groups compared to placebo ( < 0.001). The difference in the mean FSH score between the fennel group and EPO group was not significant ( = 0.304), but the difference in the mean estradiol level between these groups was significant ( = 0.043). Moreover, there was a significant difference in the mean MRS score between the intervention groups before the intervention ( < 0.05). However, the difference in the mean MRS score between the fennel and EPO groups was not significant after the intervention ( = 0.322).
Consumption of fennel and EPO can significantly change FSH, estradiol, and psychological menopausal symptoms in postmenopausal women.
使用天然口服补充剂是过去十年中广受欢迎的补充医学方法之一。由于研究报告了草药在更年期有效性方面相互矛盾的结果，且尚未有其他更有效的草药被提出，本研究的研究人员决定比较茴香和月见草油（EPO）及其对更年期问题和性激素的影响。
本研究是一项三盲、对照临床试验，125名参与者被随机分配。一个干预组服用茴香，另一个干预组服用月见草油，安慰剂组每天服用两次安慰剂，持续8周。干预前和干预后的结果通过激素检测和更年期评分量表（MRS）获得。
在本研究中，与安慰剂组相比，茴香组和EPO组的平均促卵泡生成素（FSH）和雌二醇水平有显著变化（<0.001）。茴香组和EPO组之间的平均FSH评分差异不显著（=0.304），但这些组之间的平均雌二醇水平差异显著（=0.043）。此外，干预组干预前的平均MRS评分存在显著差异（<0.05）。然而，干预后茴香组和EPO组之间的平均MRS评分差异不显著（=0.322）。
食用茴香和EPO可显著改变绝经后女性的FSH、雌二醇和更年期心理症状。
