Riazi Hedyeh, Ghazanfarpour Masumeh, Taebi Mahboubeh, Abdolahian Somayeh
Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nursing and Midwifery, Razi School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
J Menopausal Med. 2019 Dec;25(3):109-116. doi: 10.6118/jmm.19194.
Menopause is associated with the onset of climacteric symptoms due to low estradiol levels, which may cause insufficient maturation of the vaginal mucosa. Vitamin D may regulate the growth and differentiation of cells that are adversely affected due to low estradiol levels, thereby restoring vaginal health. The objective of this systematic review, the first on this subject, was to investigate the effect of vitamin D on the vaginal health of menopausal women. PubMed, Embase, Scopus, Web of Science, and Google Scholar databases and reference lists of hand-searched articles were searched for published studies from February 2000 to November 2018. The selection criteria were as follows: randomized or quasi-randomized trials that compared the effects of vitamin D or related compounds, alone or with calcium, on vaginal health (growth and differentiation of epithelial cells, dryness, acidity [pH]) outcomes in menopausal women. The methodological quality of these studies was examined using the Cochrane tool checklist by two independent investigators, following which the data were extracted. Of six examined studies, two showed that vitamin D administration improved the growth and differentiation of vaginal epithelial cells, improved vaginal pH, and decreased vaginal dryness in menopausal women. Although the level of evidence for the effects of vitamin D on vaginal health is low in our study, we concluded that vitamin D may improve the vaginal health of women, especially during menopause.
绝经与由于雌二醇水平低而出现的更年期症状有关，这可能导致阴道黏膜成熟不足。维生素D可能调节因雌二醇水平低而受到不利影响的细胞的生长和分化，从而恢复阴道健康。本系统评价是关于该主题的首个评价，其目的是研究维生素D对绝经后女性阴道健康的影响。检索了PubMed、Embase、Scopus、Web of Science和谷歌学术数据库以及手工检索文章的参考文献列表，以查找2000年2月至2018年11月发表的研究。选择标准如下：比较维生素D或相关化合物单独或与钙联合使用对绝经后女性阴道健康（上皮细胞的生长和分化、干燥、酸度[pH值]）结局影响的随机或半随机试验。两名独立研究人员使用Cochrane工具清单检查了这些研究的方法学质量，随后提取了数据。在六项审查的研究中，两项研究表明，给予维生素D可改善绝经后女性阴道上皮细胞的生长和分化，改善阴道pH值，并减轻阴道干燥。尽管在我们的研究中，维生素D对阴道健康影响的证据水平较低，但我们得出结论认为，维生素D可能改善女性的阴道健康，尤其是在绝经期间。
