GrimAge 加速与冠状动脉风险发展在年轻人（CARDIA）研究中的肺功能之间的关联。
Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
机构信息
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Department of Epidemiology of Health Statistics, School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201318, China.
出版信息
Epigenomics. 2023 Jul;15(13):693-703. doi: 10.2217/epi-2023-0164. Epub 2023 Sep 11.
The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. At Y20, forced expiratory volume in 1 s (FEV) and FEV/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.
本研究旨在确定肺功能是否与表观遗传衰老（GrimAge）相关，以及 GrimAge 是否可预测肺气肿。这项前瞻性研究纳入了作为基于社区的纵向队列的一部分的 1042 名参与者。研究在研究年份（Y）20 时（参与者年龄为 40-45 岁）检查了肺功能和 GrimAge 之间的横断面关联，并在 Y25 时检查了与肺气肿的前瞻性关联。在 Y20 时，1 秒用力呼气量（FEV）和 FEV/用力肺活量（FVC）与 GrimAge 呈负相关；对于 Y0-Y10 的累积指标，只有 FEV/FVC 比值与 Y15 和 Y20 的 GrimAge 相关。Y25 时的肺气肿与 Y15 和 Y20 时的 GrimAge 相关。肺功能与中年早期和中期的 GrimAge 相关；GrimAge 部分中介了肺功能与肺气肿之间的关联。
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