Karaca Emine Esra, Işık Feyza Dicle, Kemer Özlem Evren
Department of Ophthalmology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye.
Korean J Transplant. 2023 Sep 30;37(3):203-209. doi: 10.4285/kjt.23.0032. Epub 2023 Sep 11.
Descemet membrane endothelial keratoplasty (DMEK) is increasingly favored in the treatment of endothelial dysfunction due to its benefits, which include swift visual rehabilitation and recovery, a relatively low rejection rate, and superior refractive stability. In this study, we examined alterations in corneal clarity among patients who underwent DMEK and correlated these densitometry findings with other optical parameters of corneal topography.
The study incorporated 35 eyes from 35 patients who had previously undergone DMEK surgery for pseudophakic bullous keratopathy at Ankara Bilkent City Hospital. The results from these patients were compared with those from a healthy control group. The preoperative and postoperative optical parameters of the patients were assessed using Pentacam Scheimpflug topography (Oculus).
We observed significant decreases in corneal densitometry in the 0-2 mm and 2-6 mm zones of the anterior, posterior, central, and total layers at the sixth month postoperatively compared to the preoperative period (P<0.05). The corneal densitometry values at postoperative month 6 were elevated in all layers and zones relative to the healthy group (P<0.05). The root mean square of higher-order aberrations in postoperative period was elevated significantly (P<0.001).
Six months after operation, the optical quality of the cornea following DMEK surgery did not achieve the level of a healthy cornea.
由于具有快速视力恢复、相对较低的排斥率和卓越的屈光稳定性等优点，Descemet膜内皮角膜移植术（DMEK）在治疗内皮功能障碍方面越来越受到青睐。在本研究中，我们检查了接受DMEK手术患者的角膜透明度变化，并将这些密度测量结果与角膜地形图的其他光学参数相关联。
该研究纳入了安卡拉比尔肯特市医院35例因假晶状体大疱性角膜病变先前接受DMEK手术患者的35只眼。将这些患者的结果与健康对照组的结果进行比较。使用Pentacam Scheimpflug地形图（Oculus）评估患者术前和术后的光学参数。
与术前相比，术后第六个月，前、后、中央和全层的0-2mm和2-6mm区域角膜密度测量值显著降低（P<0.05）。与健康组相比，术后第6个月所有层和区域的角膜密度测量值均升高（P<0.05）。术后高阶像差的均方根显著升高（P<0.001）。
DMEK手术后6个月，角膜的光学质量未达到健康角膜的水平。
