Pachuashvili N V, Roslyakova A A, Porubayeva E E, Beltsevich D G, Gadzyra A N, Drogalov N A, Lazareva A A, Urusova L S
Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University.
Endocrinology Research Center.
Probl Endokrinol (Mosk). 2023 Aug 30;69(4):11-20. doi: 10.14341/probl13195.
Differentiation between benign, primary and secondary malignant tumors is a critical problem in the clinical treatment of adrenal tumors, especially in patients with isolated adrenal lesions. In most cases, the correct diagnosis can be established microscopically with standard staining with hematoxylin and eosin. However, there are cases when it is almost impossible to distinguish metastasis from primary adrenal cancer, so an accurate diagnosis requires an immunohistochemical examination.This article presents five unique observations of secondary adrenal tumors that were diagnosed by us in the current surgical material: metastasis of clear cell renal cell carcinoma, follicular variant of papillary thyroid cancer, metastasis of keratinizing squamous cell carcinoma of the cervix, lymphoepithelioma-like carcinoma of the bladder, as well as malignant mesothelioma. Taking into account the extreme rarity of the presented observations, we present an analysis of the literature data.
区分肾上腺肿瘤的良性、原发性和继发性恶性肿瘤是肾上腺肿瘤临床治疗中的一个关键问题，尤其是在孤立性肾上腺病变患者中。在大多数情况下，通过苏木精和伊红标准染色可在显微镜下做出正确诊断。然而，在某些情况下，几乎无法区分转移瘤与原发性肾上腺癌，因此准确诊断需要进行免疫组化检查。本文介绍了我们在当前手术材料中诊断出的5例继发性肾上腺肿瘤的独特病例：透明细胞肾细胞癌转移、甲状腺乳头状癌滤泡变体、宫颈角化性鳞状细胞癌转移、膀胱淋巴上皮瘤样癌以及恶性间皮瘤。考虑到所呈现病例的极端罕见性，我们对文献数据进行了分析。
