Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands
Behav Brain Sci. 2023 Sep 11;46:e184. doi: 10.1017/S0140525X22002229.
Madole & Harden argue that the Mendelian reshuffling of genes and genomes is analogous to randomised controlled trials. We are not convinced by their arguments. First, their recipe for meeting the demands on randomised experiments is inherently inconsistent. Second, disequilibrium across chromosomes conflicts with their assumption of statistical independence. Third, the genome-wide association study (GWAS) method has many pitfalls, including low repeatability.
马多勒和哈登认为，孟德尔式的基因和基因组重排类似于随机对照试验。我们并不认同他们的观点。首先，他们满足随机实验要求的方法本质上是不一致的。其次，染色体间的不平衡与他们假设的统计独立性相冲突。第三，全基因组关联研究（GWAS）方法存在许多缺陷，包括可重复性低。
