School of Natural and Social Sciences, Purchase College, State University of New York, Purchase, NY, USA
Behav Brain Sci. 2023 Sep 11;46:e200. doi: 10.1017/S0140525X22002230.
Madole & Harden's assertion that the effects derived from within-family genome-wide association studies (GWASs) and from randomized controlled trials (RCTs) are equivalent is misleading. GWASs are substantially more "non-unitary, non-uniform, and non-explanatory" than RCTs. While the within-family GWAS bring us closer to identifying genetic causes, whether it will change behavioral genetics into a causal science is an open question.
马多勒和哈登断言，从家族内全基因组关联研究（GWAS）和随机对照试验（RCT）中得出的效果是等效的，这是具有误导性的。GWAS 比 RCT 更具“非单一性、非均匀性和非解释性”。虽然家族内的 GWAS 使我们更接近识别遗传原因，但它是否会将行为遗传学转变为因果科学，这仍是一个悬而未决的问题。
