Zhu Fujun, Wang Shaolian, Zhu Xianglian, Pang Caixiang, Cui Pei, Yang Fuwang, Li Rongsheng, Zhan Qiu, Xin Haiming
Department of Burns and Plastic Surgery, the No. 924th Hospital of the Joint Logistic Support Force of the Chinese PLA, Guilin, Guangxi 541002, People's Republic of China.
Central Sterile Supply Department, the No. 924th Hospital of the Joint Logistic Support Force of the Chinese PLA, Guilin, Guangxi 541002, People's Republic of China.
Biomater Sci. 2023 Oct 24;11(21):6977-7002. doi: 10.1039/d3bm01213a.
The use of biomaterials in biomedicine and healthcare has increased in recent years. Macrophages are the primary immune cells that induce inflammation and tissue repair after implantation of biomaterials. Given that macrophages exhibit high heterogeneity and plasticity, the influence of biomaterials on macrophage phenotype should be considered a crucial evaluation criterion during the development of novel biomaterials. This review provides a comprehensive summary of the physicochemical, biological, and dynamic characteristics of biomaterials that drive the regulation of immune responses in macrophages. The mechanisms involved in the interaction between macrophages and biomaterials, including endocytosis, receptors, signalling pathways, integrins, inflammasomes and long non-coding RNAs, are summarised in this review. In addition, research prospects of the interaction between macrophages and biomaterials are discussed. An in-depth understanding of mechanisms underlying the spatiotemporal changes in macrophage phenotype induced by biomaterials and their impact on macrophage polarization can facilitate the identification and development of novel biomaterials with superior performance. These biomaterials may be used for tissue repair and regeneration, vaccine or drug delivery and immunotherapy.
近年来，生物材料在生物医学和医疗保健中的应用有所增加。巨噬细胞是生物材料植入后引发炎症和组织修复的主要免疫细胞。鉴于巨噬细胞具有高度的异质性和可塑性，在新型生物材料的研发过程中，生物材料对巨噬细胞表型的影响应被视为一项关键的评估标准。本综述全面总结了驱动巨噬细胞免疫反应调节的生物材料的物理化学、生物学和动态特性。本综述还总结了巨噬细胞与生物材料相互作用所涉及的机制，包括内吞作用、受体、信号通路、整合素、炎性小体和长链非编码RNA。此外，还讨论了巨噬细胞与生物材料相互作用的研究前景。深入了解生物材料诱导巨噬细胞表型时空变化的机制及其对巨噬细胞极化的影响，有助于识别和开发性能卓越的新型生物材料。这些生物材料可用于组织修复与再生、疫苗或药物递送以及免疫治疗。
