Spier S, Rivlin J, Rowe R D, Egan T
Chest. 1986 Nov;90(5):711-5. doi: 10.1378/chest.90.5.711.
Eight patients (aged 8 to 22 years) with the Pierre Robin syndrome underwent sleep studies. Seven demonstrated significant although minor degrees of increased sleep disturbances and apneas, and less time spent in the rapid-eye-movement (REM) stage of sleep. One patient who had previously undergone mandibular corrective surgery had major sleep abnormalities (central apnea index of 81.7 although an obstructive sleep apnea index of only 1.9). The patients had small mandibles, as demonstrated by lateral cephalometric roentgenography, and mildly increased right ventricular diastolic dimensions, as shown by M-mode echocardiography. Snoring was present in all of these patients and in 13 of 22 patients questioned from our Pierre Robin clinic. We conclude that minor abnormalities in sleep, mandibular size, and right ventricular size persist well into adolescence in the majority of patients with Pierre Robin syndrome. These appear to be clinically insignificant; however, a small percentage of such patients may continue to have major sleep disturbances.
8名患有皮埃尔·罗宾综合征的患者（年龄在8至22岁之间）接受了睡眠研究。7名患者表现出明显但程度较轻的睡眠障碍和呼吸暂停增加，且快速眼动（REM）睡眠阶段的时间减少。1名先前接受过下颌矫正手术的患者存在严重的睡眠异常（中枢性呼吸暂停指数为81.7，而阻塞性睡眠呼吸暂停指数仅为1.9）。通过头颅侧位X线片显示，这些患者下颌较小；通过M型超声心动图显示，右心室舒张尺寸轻度增加。所有这些患者均有打鼾现象，在我们皮埃尔·罗宾诊所接受询问的22名患者中有13名也存在打鼾。我们得出结论，大多数皮埃尔·罗宾综合征患者在青春期仍存在睡眠、下颌大小和右心室大小的轻微异常。这些异常在临床上似乎并不重要；然而，一小部分此类患者可能会继续出现严重的睡眠障碍。
