Riley Hospital for Children Division of Pediatric Hematology and Oncology at Indiana University Health.
Center for Pediatric and Adolescent Comparative Effectiveness Research, Indiana University.
J Pediatr Hematol Oncol. 2023 Nov 1;45(8):e940-e947. doi: 10.1097/MPH.0000000000002752. Epub 2023 Sep 8.
Human papillomavirus (HPV) vaccination prevents the development of HPV-associated malignancies. Adolescent and young adult survivors of childhood cancers and patients with sickle cell disease (SCD) are vulnerable patient populations who would significantly benefit from HPV vaccination. In this multimethod study, a retrospective chart review found a notable difference between the rate of HPV vaccinations and other age-appropriate vaccinations in 177 childhood cancer survivors and in 70 patients with SCD. We then sought to describe patient and caregiver beliefs regarding HPV vaccination, through semistructured interviews with 21 patients and 48 caregivers. Interviews were analyzed with a thematic content approach to understand attitudes regarding the HPV vaccination. Qualitative interviews noted that many caregivers and adolescents had baseline misconceptions regarding the HPV vaccination in general and in context with their chronic illness. It was found that a strong recommendation from a trusted subspecialty provider would create reassurance about vaccination and reduce misconceptions and concerns about side effects in the context of a chronic illness. Counseling from subspecialists could have a strong impact on understanding the HPV vaccine in the context of chronic illness. This would likely help overcome many of the barriers to vaccination that are encountered by patients with SCD or oncology survivors.
人乳头瘤病毒（HPV）疫苗接种可预防 HPV 相关恶性肿瘤的发生。儿童癌症的青少年和年轻成年幸存者以及镰状细胞病（SCD）患者是易受感染的人群，他们将从 HPV 疫苗接种中显著受益。在这项多方法研究中，通过对 177 名儿童癌症幸存者和 70 名 SCD 患者的回顾性图表审查，发现 HPV 疫苗接种率与其他适龄疫苗接种率之间存在显著差异。然后，我们通过对 21 名患者和 48 名照顾者进行半结构化访谈，试图描述患者和照顾者对 HPV 疫苗接种的信念。采用主题内容分析法对访谈进行分析，以了解他们对 HPV 疫苗接种的态度。定性访谈指出，许多照顾者和青少年对 HPV 疫苗接种一般以及在与慢性疾病相关的方面存在基本误解。结果发现，来自受信任的专科医生的强烈推荐将有助于对疫苗接种产生信心，并减少对慢性病相关副作用的误解和担忧。专科医生的咨询将对了解慢性病背景下的 HPV 疫苗产生重大影响。这可能有助于克服 SCD 患者或肿瘤幸存者在接种疫苗时遇到的许多障碍。
