The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
The Third People's Hospital of Huizhou, Huizhou, China.
Sci Rep. 2023 Sep 11;13(1):14928. doi: 10.1038/s41598-023-42206-x.
Insulin resistance (IR) is associated with a variety of cardiovascular diseases, but there are few studies on the correlation between IR and calcified aortic stenosis (CAS). In this study, the triglyceride-glucose (TyG) index, which reflects IR, was used to investigate the correlation between IR and CAS. The study included 183 elderly patients who were diagnosed with CAS by transthoracic echocardiography. The patients were matched 1:1 according to age and sex, and elderly patients who were hospitalized during the same period and underwent transthoracic echocardiography without aortic stenosis were included as the control group. The relationship between the TyG index and CAS was analyzed by a multivariable logistic regression model, curve fitting and trend test. Multivariate logistic regression analysis showed that the TyG index as a continuous variable was negatively associated with CAS (P < 0.001); trend tests and curve fitting further supported this association. Our study showed that the TyG index was negatively associated with CAS in elderly patients, which may be related to the impairment of insulin receptors and signaling pathways in IR.
胰岛素抵抗（IR）与多种心血管疾病相关，但关于 IR 与钙化性主动脉狭窄（CAS）之间的相关性的研究较少。本研究使用反映 IR 的三酰甘油-葡萄糖（TyG）指数来探讨 IR 与 CAS 之间的相关性。该研究纳入了 183 名经胸超声心动图诊断为 CAS 的老年患者。根据年龄和性别进行 1:1 配对，选择同期住院且经胸超声心动图检查无主动脉狭窄的老年患者作为对照组。通过多变量逻辑回归模型、曲线拟合和趋势检验分析 TyG 指数与 CAS 之间的关系。多变量逻辑回归分析显示，TyG 指数作为连续变量与 CAS 呈负相关（P<0.001）；趋势检验和曲线拟合进一步支持这种关联。本研究表明，TyG 指数与老年患者的 CAS 呈负相关，这可能与 IR 中胰岛素受体和信号通路的损伤有关。
