Chen Zhihao, Liu Luyao, Jiao Xueyan, Zhang Yifan, Wang Fei, Chen Yun, Lan Zhenzhen, Liu Xincan
Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China.
The First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
BMC Cardiovasc Disord. 2024 Dec 19;24(1):708. doi: 10.1186/s12872-024-04372-2.
The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the development of calcific aortic valve disease (CAVD), thereby extending its applicability in cardiovascular diagnostics.
Data from 400 individuals, comprising 200 patients with diagnosed CAVD and 200 matched healthy controls, were analyzed. Clinical parameters were compared between groups, and logistic regression was utilized to explore the association of the TG/HDL-C ratio with CAVD. The diagnostic performance of the TG/HDL-C ratio was assessed using receiver operating characteristic (ROC) curves.
The TG/HDL-C ratio was notably higher in the CAVD group than in the controls (Z = -7.98, P < 0.001). Multivariable logistic regression analysis indicated that the TG/HDL-C ratio is an independent predictor of CAVD after adjusting for confounders including gender. The ROC curve analysis revealed that the TG/HDL-C ratio achieved a sensitivity of 80.5%, a specificity of 59.5%, and an area under the curve (AUC) of 0.731 (P < 0.001), confirming its efficacy in predicting CAVD.
High TG/HDL-C ratio was significantly associated with the occurrence of CAVD, and the TG/HDL-C ratio could be used as a potential diagnostic tool and risk assessment indicator for CAVD.
Not applicable.
甘油三酯与高密度脂蛋白胆固醇的比值（TG/HDL-C）越来越被认为是胰岛素抵抗和心血管风险评估的实用指标。这项回顾性研究调查了TG/HDL-C比值预测钙化性主动脉瓣疾病（CAVD）发生的潜力，从而扩展其在心血管诊断中的适用性。
分析了400名个体的数据，其中包括200名确诊为CAVD的患者和200名匹配的健康对照。比较了两组之间的临床参数，并使用逻辑回归来探讨TG/HDL-C比值与CAVD的关联。使用受试者工作特征（ROC）曲线评估TG/HDL-C比值的诊断性能。
CAVD组的TG/HDL-C比值显著高于对照组（Z = -7.98，P < 0.001）。多变量逻辑回归分析表明，在调整包括性别在内的混杂因素后，TG/HDL-C比值是CAVD的独立预测因子。ROC曲线分析显示，TG/HDL-C比值的敏感性为80.5%，特异性为59.5%，曲线下面积（AUC）为0.731（P < 0.001），证实了其在预测CAVD方面的有效性。
高TG/HDL-C比值与CAVD的发生显著相关，TG/HDL-C比值可作为CAVD的潜在诊断工具和风险评估指标。
不适用。
