血清软骨寡聚基质蛋白浓度在老年人跑步后增加比游泳后更多。
Serum Cartilage Oligomeric Matrix Protein Concentration Increases More After Running Than Swimming for Older People.
机构信息
Department of Exercise Sciences, Brigham Young University, Provo, Utah.
Department of Statistics, Brigham Young University, Provo, Utah.
出版信息
Sports Health. 2024 Jul-Aug;16(4):534-541. doi: 10.1177/19417381231195309. Epub 2023 Sep 11.
BACKGROUND
Knee osteoarthritis is common in older people. Serum cartilage oligomeric matrix protein (sCOMP) is a biomarker of knee articular cartilage metabolism. The purpose of this study was 2-fold: to (1) determine acute effects of running and swimming on sCOMP concentration in older people; and (2) investigate relationships between sCOMP concentration change due to running and swimming and measures of knee health in older people.
HYPOTHESES
Running would result in greater increase in sCOMP concentration than swimming, and increase in sCOMP concentration due to running and swimming would associate positively with measures of poor knee health.
STUDY DESIGN
Cross-sectional.
LEVEL OF EVIDENCE
Level 3.
METHODS
A total of 20 participants ran 5 km and 19 participants swam 1500 m. sCOMP concentration was measured immediately before, immediately after, and 15, 30, and 60 minutes after running or swimming. sCOMP concentration change due to running and swimming was compared. Correlations between sCOMP concentration change due to running and swimming, and other measures of knee health were evaluated, including the Tegner Activity Scale and Knee injury and Osteoarthritis Outcome Score.
RESULTS
sCOMP concentration increased 29% immediately after running, relative to baseline, but only 6% immediately after swimming ( < 0.01). No significant relationship was observed between acute sCOMP change due to running and swimming, and observed measures of knee health ( > 0.05). Participants with clinically relevant knee symptoms exhibited greater sCOMP concentration before and after running and swimming ( = 0.03) and had greater body mass ( = 0.04).
CONCLUSION
Running results in greater acute articular cartilage metabolism than swimming; however, the chronic effects of this are unclear. Older people with clinically relevant knee symptoms possess greater sCOMP concentration and are heavier, independent of exercise mode and physical activity level.
CLINICAL RELEVANCE
These results describe the effects of exercise (running and swimming) for older physically active persons, with and without knee pain.
背景
膝骨关节炎在老年人中较为常见。血清软骨寡聚基质蛋白（sCOMP）是膝关节软骨代谢的生物标志物。本研究的目的有两个：（1）确定跑步和游泳对老年人 sCOMP 浓度的急性影响；（2）探讨跑步和游泳引起的 sCOMP 浓度变化与老年人膝关节健康指标之间的关系。
假设
跑步会导致 sCOMP 浓度的增加大于游泳，且跑步和游泳引起的 sCOMP 浓度的增加与膝关节健康状况的恶化呈正相关。
研究设计
横断面研究。
证据水平
3 级。
方法
共 20 名参与者跑步 5 公里，19 名参与者游泳 1500 米。在跑步或游泳前、后即刻以及 15、30 和 60 分钟测量 sCOMP 浓度。比较跑步和游泳引起的 sCOMP 浓度变化。评估跑步和游泳引起的 sCOMP 浓度变化与其他膝关节健康指标（包括 Tegner 活动量表和膝关节损伤和骨关节炎结果评分）之间的相关性。
结果
与基线相比，跑步后 sCOMP 浓度立即增加了 29%，而游泳后仅增加了 6%（<0.01）。跑步和游泳引起的 sCOMP 浓度变化与观察到的膝关节健康指标之间未观察到显著关系（>0.05）。有临床相关膝关节症状的参与者在跑步和游泳前后的 sCOMP 浓度更高（=0.03），且体重更大（=0.04）。
结论
跑步引起的急性关节软骨代谢比游泳更为剧烈；然而，其慢性影响尚不清楚。有临床相关膝关节症状的老年人具有更高的 sCOMP 浓度，且体重更大，这与运动方式和身体活动水平无关。
临床相关性
这些结果描述了运动（跑步和游泳）对有或无膝关节疼痛的老年活跃人群的影响。
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