Pen-Tung Sah Institute of Micro-Nano Science and Technology, Xiamen University, Xiamen, 361102, China.
The State Key Laboratory of Fluid Power & Mechatronic Systems, Zhejiang University, Hangzhou 310027, China.
Analyst. 2023 Sep 25;148(19):4637-4654. doi: 10.1039/d3an00981e.
Implantable microfluidics involves integrating microfluidic functionalities into implantable devices, such as medical implants or bioelectronic devices, revolutionizing healthcare by enabling personalized and precise diagnostics, targeted drug delivery, and regeneration of targeted tissues or organs. The impact of implantable microfluidics depends heavily on advancements in both methods and applications. Despite significant progress in the past two decades, continuous advancements are still required in fluidic control and manipulation, device miniaturization and integration, biosafety considerations, as well as the development of various application scenarios to address a wide range of healthcare issues. In this review, we discuss advancements in implantable microfluidics, focusing on methods and applications. Regarding methods, we discuss progress made in fluid manipulation, device fabrication, and biosafety considerations in implantable microfluidics. In terms of applications, we review advancements in using implantable microfluidics for drug delivery, diagnostics, tissue engineering, and energy harvesting. The purpose of this review is to expand research ideas for the development of novel implantable microfluidic devices for various healthcare applications.
植入式微流控涉及将微流控功能集成到植入式设备中，例如医疗植入物或生物电子设备，通过实现个性化和精确的诊断、靶向药物输送以及目标组织或器官的再生，彻底改变了医疗保健。植入式微流控的影响在很大程度上取决于方法和应用的进步。尽管在过去的二十年中取得了重大进展，但仍需要在流控控制和操作、设备小型化和集成、生物安全性考虑以及各种应用场景的开发方面不断取得进展，以解决广泛的医疗保健问题。在这篇综述中，我们讨论了植入式微流控的进展，重点介绍了方法和应用。在方法方面，我们讨论了在植入式微流控中流体操控、设备制造和生物安全性考虑方面的进展。在应用方面，我们综述了使用植入式微流控进行药物输送、诊断、组织工程和能量收集方面的进展。本综述的目的是为各种医疗保健应用中新型植入式微流控设备的开发扩展研究思路。
