School of Biotechnology, National Institute of Technology, Calicut, Kerala, India.
Institute of Advanced Energy, Kyoto University, Kyoto, Japan.
Curr Pharm Des. 2022;28(9):679-689. doi: 10.2174/1381612827666210825114403.
Implantable microfluidic devices are milestones in developing devices that can measure parameters like ocular pressure and blood glucose level or deliver various components for therapeutic needs or behavioral modification. Researchers are currently focusing on the miniaturization of almost all its tools for a better healthcare platform. Implantable microfluidic devices are a combination of various systems including, but not limited to, microfluidic platforms, reservoirs, sensors, and actuators, implanted inside the body of a living entity (in vivo) with the purpose of directly or indirectly helping the entity. It is a multidisciplinary approach with immense potential in the area of the biomedical field. Significant resources are utilized for the research and development of these devices for various applications. The induction of an implantable microfluidic device into an animal would enable us to measure the responses without any repeated invasive procedures. Such data would help in the development of a better drug delivery profile. Implantable microfluidic devices with reservoirs deliver specific chemical or biological products to treat situations like cancers and diabetes. They can also deliver fluorophores for specific imaging inside the body. Implantable microfluidic devices help provide a microenvironment for various cell differentiation procedures. These devices know no boundaries, and this article reviews these devices based on their design and applications.
可植入微流控装置是开发能够测量眼压和血糖水平等参数或输送各种治疗所需或行为修正组件的设备的里程碑。研究人员目前专注于几乎所有工具的小型化，以提供更好的医疗保健平台。可植入微流控装置是各种系统的组合，包括但不限于微流控平台、储液器、传感器和执行器，它们被植入活体（体内）内部，目的是直接或间接地帮助实体。这是一个多学科的方法，在生物医学领域具有巨大的潜力。为了研究和开发这些用于各种应用的设备，投入了大量资源。将可植入微流控装置引入动物体内，可以使我们在无需进行任何重复侵入性程序的情况下测量反应。这些数据将有助于开发更好的药物输送方案。带有储液器的可植入微流控装置可输送特定的化学或生物产品，以治疗癌症和糖尿病等情况。它们还可以输送荧光团，用于体内特定成像。可植入微流控装置有助于为各种细胞分化程序提供微环境。这些装置没有界限，本文根据其设计和应用对这些装置进行了综述。
