Alexandre-Franco María F, Kouider Rahmani, Kassir Al-Karany Raúl, Cuerda-Correa Eduardo M, Al-Kassir Awf
Departamento de Química Orgánica e Inorgánica, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06006 Badajoz, Spain.
Department of Technology, Ziane Achour University of Djelfa, Djelfa 17000, Algeria.
Micromachines (Basel). 2024 Sep 6;15(9):1137. doi: 10.3390/mi15091137.
This review explores significant advancements in polymer science and fabrication processes that have enhanced the performance and broadened the application scope of microfluidic devices. Microfluidics, essential in biotechnology, medicine, and chemical engineering, relies on precise fluid manipulation in micrometer-sized channels. Recent innovations in polymer materials, such as flexible, biocompatible, and structurally robust polymers, have been pivotal in developing advanced microfluidic systems. Techniques like replica molding, microcontact printing, solvent-assisted molding, injection molding, and 3D printing are examined, highlighting their advantages and recent developments. Additionally, the review discusses the diverse applications of polymer-based microfluidic devices in biomedical diagnostics, drug delivery, organ-on-chip models, environmental monitoring, and industrial processes. This paper also addresses future challenges, including enhancing chemical resistance, achieving multifunctionality, ensuring biocompatibility, and scaling up production. By overcoming these challenges, the potential for widespread adoption and impactful use of polymer-based microfluidic technologies can be realized.
本综述探讨了聚合物科学和制造工艺的重大进展，这些进展提高了微流控装置的性能并拓宽了其应用范围。微流控技术在生物技术、医学和化学工程中至关重要，它依赖于在微米级通道中对流体进行精确操控。聚合物材料的最新创新，如柔性、生物相容性和结构坚固的聚合物，在开发先进的微流控系统中发挥了关键作用。文中研究了复制成型、微接触印刷、溶剂辅助成型、注射成型和3D打印等技术，突出了它们的优点和最新进展。此外，该综述还讨论了基于聚合物的微流控装置在生物医学诊断、药物递送、芯片器官模型、环境监测和工业过程中的多种应用。本文还探讨了未来的挑战，包括提高耐化学性、实现多功能性、确保生物相容性以及扩大生产规模。通过克服这些挑战，可以实现基于聚合物的微流控技术广泛应用和产生重大影响的潜力。
