Academician Workstation, Affiliated Hospital of North Sichuan Medical College Nanchong, Nanchong, 637000, P. R. China.
Department of Infectious Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, P. R. China.
Adv Healthc Mater. 2023 Nov;12(29):e2300819. doi: 10.1002/adhm.202300819. Epub 2023 Sep 21.
Radiation-induced heart disease is a serious side effect of radiation therapy that can lead to severe consequences. However, effective and safe methods for their prevention and treatment are presently lacking. This study reports the crucial function of fullerenols in protecting cardiomyocytes from radiation injury. First, fullerenols are synthesized using a simple base-catalyzed method. Next, the as-prepared fullerenols are applied as an effective free radical scavenger and broad-spectrum antioxidant to protect against X-ray-induced cardiomyocyte injury. Their ability to reduce apoptosis via the mitochondrial signaling pathway at the cellular level is then verified. Finally, it is observed in animal models that fullerenols accumulate in the heart and alleviate myocardial damage induced by X-rays. This study represents a timely and essential analysis of the prevention and treatment of radiological myocardial injury, providing new insights into the applications of fullerenols for therapeutic strategies.
辐射性心脏病是放射治疗的一种严重副作用，可导致严重后果。然而，目前缺乏有效的、安全的预防和治疗方法。本研究报告了富勒醇在保护心肌细胞免受辐射损伤方面的关键作用。首先，采用简单的碱催化方法合成富勒醇。接下来，将制备的富勒醇用作有效的自由基清除剂和广谱抗氧化剂，以防止 X 射线诱导的心肌细胞损伤。然后在细胞水平上通过线粒体信号通路验证其减少细胞凋亡的能力。最后，在动物模型中观察到富勒醇在心内蓄积，并减轻 X 射线引起的心肌损伤。本研究及时而必要地分析了放射性心肌损伤的预防和治疗，为富勒醇在治疗策略中的应用提供了新的见解。
