Cai Tao, Liu Yuwan, Zhu Leilei, Su Hao, Wang Yu, Wang Guokun, Zhang Lingling, Zhu Zhiguang, Sheng Xiang, Bi Changhao, Ma Hongwu, Tian Chaoguang, Zhang Xueli, Wu Qiaqing, Sun Yuanxia, Jiang Huifeng, Ma Yanhe
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2022 Nov 25;38(11):4101-4114. doi: 10.13345/j.cjb.220889.
Utilization of carbon dioxide (CO) is a huge challenge for global sustainable development. Biological carbon fixation occurs in nature, but the low energy efficiency and slow speed hamper its commercialization. Physical-chemical carbon fixation is efficient, but relies on high energy consumption and often generates unwanted by-products. Combining the advantages of biological, physical and chemical technologies for efficient utilization of CO remains to be an urgent scientific and technological challenge to be addressed. Here, based on the development of Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences in the past decade, we summarize the important progress in the design and construction of functional parts, pathways and systems for artificial bioconversion of carbon dioxide, including the breakthrough on the artificial synthesis of starch from CO. Moreover, we prospect how to further develop the technologies for artificial bioconversion of carbon dioxide. These progress and perspectives provide new insight for achieving the goal of "carbon peaking and carbon neutrality".
二氧化碳（CO）的利用是全球可持续发展面临的巨大挑战。生物固碳在自然界中存在，但能量效率低和速度慢阻碍了其商业化。物理化学固碳效率高，但依赖高能耗且常产生不需要的副产物。结合生物、物理和化学技术优势实现二氧化碳高效利用仍是亟待解决的重大科技挑战。在此，基于中国科学院天津工业生物技术研究所过去十年的发展，我们总结了二氧化碳人工生物转化功能部件、途径和系统设计与构建方面的重要进展，包括从二氧化碳人工合成淀粉的突破。此外，我们展望了如何进一步发展二氧化碳人工生物转化技术。这些进展和展望为实现“碳达峰、碳中和”目标提供了新的思路。
