Chen Xi, Wu Fengli, Fan Feiyu, Wu Qiaqing, Zhu Dunming
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2022 Nov 25;38(11):4240-4262. doi: 10.13345/j.cjb.220588.
In nature, chirality is a common phenomenon and closely related to life, also significantly influences the properties of the substance. The chemical synthesis of chiral pharmaceutical chemicals has encountered challenges such as poor atom economy and process economy, serious environmental pollution and waste of the resource. The biosynthesis route has the advantages of high selectivity and environmental-friendliness. In recent years, the rapid developments in the accessible key enzymes, understanding of catalytic mechanism, construction of new synthetic pathways of optical pure intermediates, process development and scale-up production have made it possible to address the challenges encountered in the production of active pharmaceutical ingredients, thus promoting a green and sustainable pharmaceutical industry in China. This review summarized the achievements made in this field by researchers at Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences.
